Decorative

The Meng Lab of Molecular Virology

The Meng lab studies emerging and zoonotic viruses of veterinary and human public health significance, delineates the molecular mechanisms of virus replication, pathogenesis and cross-species infection, and develop life-saving effective vaccines against viruses, including hepatitis E virus (HEV), coronaviruses such as SARS-CoV-2 and porcine epidemic diarrhea virus (PEDV), porcine reproductive and respiratory syndrome virus (PRRSV), porcine circovirus type 2 (PCV2), and Torque teno sus viruses (TTSuVs). Our current main research focus is on the hepatitis E virus.

HEV is an important but understudied human pathogen. According to the WHO, annually there are >20 million HEV infections worldwide leading to 3.3 million cases of symptomatic hepatitis E and 44,000 deaths. Our group discovered swine hepatitis E virus (swine HEV) and avian hepatitis E virus (avian HEV), and developed HEV reverse genetic systems. Currently we try to determine the viral and host factors contributing to cross-species HEV infection, delineate the mechanisms of chronic HEV infection, HEV neuroinvasion, and HEV-associated fulminant hepatic failure during pregnancy.

Representative Publications

  • Bo Wang, S. Subramaniam, D. Tian, H.M. Mahsoub, C.L. Heffron, and X.J. Meng. 2024. Phosphorylation of Ser711 residue in the hypervariable region of zoonotic genotype 3 hepatitis E virus is important for virus replication.  mBio. 2024 Oct 8:e0263524. doi: 10.1128/mbio.02635-24.
  • Mahsoub HM, Heffron CL, Hassebroek AM, Sooryanarain H, Wang B, LeRoith T, Rodríguez GR, Tian D, and X.J. Meng. 2023. Fetal Loss in Pregnant Rabbits Infected with Genotype 3 Hepatitis E Virus Is Associated with Altered Inflammatory Responses, Enhanced Virus Replication, and Extrahepatic Virus Dissemination with Positive Correlations with Increased Estradiol Level. mBio. 2023 Mar 20:e0041823. doi: 10.1128/mbio.00418-23.
  • Wang B, Mahsoub HM, Li W, Heffron CL, Tian D, Hassebroek AM, LeRoith T, and X.J. Meng. 2023. Ribavirin Treatment Failure-Associated Mutation, Y1320H, in the RNA-Dependent RNA Polymerase of Genotype 3 Hepatitis E Virus (HEV) Enhances Virus Replication in a Rabbit HEV Infection Model. mBio. 2023:e0337222. doi: 10.1128/mbio.03372-22.
  • Sooryanarain H, Heffron CL, Mahsoub HM, Hassebroek AM, Wang B, Tian D, Ahmed SA, and X.J. Meng. 2022. Modulation of SOCS3 Levels via STAT3 and Estrogen-ERαp66 Signaling during Hepatitis E Virus Replication in Hepatocellular Carcinoma Cells. Journal of Virology. 2022 Sep 14:e0100822. doi: 10.1128/jvi.01008-22.
  • Bo Wang, Tian D, Sooryanarain H, Mahsoub HM, Heffron CL, Hassebroek AM, and X.J. Meng. 2022. Two mutations in the ORF1 of genotype 1 hepatitis E virus enhance virus replication and may associate with fulminant hepatic failure. Proceedings of the National Academy of Sciences USA. 2022; August, 119(34): e2207503119. doi: 10.1073/pnas.2207503119
  • Tian D, Li W, Heffron CL, Wang B, Mahsoub HM, Sooryanarain H, Hassebroek AM, Clark-Deener S, LeRoith T, X.J. Meng. 2022. Hepatitis E virus infects brain microvascular endothelial cells, crosses the blood-brain barrier, and invades the central nervous system. Proceedings of the National Academy of Sciences USA. 2022 Jun 14;119(24):e2201862119. doi: 10.1073/pnas.2201862119.
  • Sooryanarain H, Ahmed SA, X.J. Meng. 2021. Progesterone-Mediated Enhancement of Hepatitis E Virus Replication in Human Liver Cells. mBio. 2021:e0143421. doi: 10.1128/mBio.01434-21.
  • Sooryanarain H, C.L. Heffron, and X.J. Meng. 2020. The U-rich untranslated regions (UTR) of the hepatitis E virus induces differential type I and type III interferon responses in a host cell-dependent manner. mBio. 11(1):e03103-19. doi: 10.1128/mBio.03103-19.
  • Sooryanarain H, C.L. Heffron, D.E. Hill, J. Fredericks, B.M. Rosenthal, S.R. Werre, T. Opriessnig, and X.J. Meng. 2020. Hepatitis E virus in pigs from slaughterhouses, United States, 2017-2019. Emerging Infectious Diseases. 26(2);354-357. DOI: 10.3201/eid2602.191348.
  • Yugo DM, C.L. Heffron, J. Ryu, K. Uh, S. Subramaniam, S.M. Matzinger, C. Overend, D.J. Cao, S.P. Kenney, H. Sooryanarain, T. Cecere, T. LeRoith, L. Yuan, N. Jue, S. Clark-Deener, K. Lee, and X.J. Meng. 2018. Infection dynamics of hepatitis E virus in wild-type and immunoglobulin heavy chain knockout JH (-/-) gnotobiotic piglets. Journal of Virology. 92(21). pii: e01208-18.
  • Sooryanarain H, A.J. Rogers, D. Cao, M.E.R. Haac, Y.A. Karpe, and X.J. Meng. 2017. ISG15 modulates type-I interferon signaling and antiviral response during hepatitis E virus replication. Journal of Virology. 91(19). pii: e00621-17. doi: 10.1128/JVI.00621-17.
  • Cao D, Cao QM, Subramaniam S, Yugo DM, Heffron CL, Rogers AJ, Kenney SP, Tian D, Matzinger SR, Overend C, Catanzaro N, LeRoith T, Wang H, Piñeyro P, Lindstrom N, Clark-Deener S, Yuan L, and X.J. Meng. 2017. Pig model mimicking chronic hepatitis E virus infection in immunocompromised patients to assess immune correlates during chronicity. Proceedings of the National Academy of Sciences USA. 114(27):6914-6923.
  • Kenney SP, and X.J. Meng. 2015. The Lysine Residues within the Human Ribosomal Protein S17 (RPS17) Sequence Naturally Inserted into the Viral Nonstructural Protein of a Unique Strain of Hepatitis E Virus are Important for Enhanced Virus Replication. Journal of Virology. 89:3793-3803.
  • Kenney S.P., R.S. Pudupakam, Y.W. Huang, F.W. Pierson, T. LeRoith, and X.J. Meng. 2012. The PSAP motif within the ORF3 protein of an avian strain of the hepatitis E virus is not critical for viral infectivity in vivo but plays a role in virus release. Journal of Virology. 86(10):5637-46.
  • Karpe Y.A., and X.J. Meng. 2012. Hepatitis E virus replication requires an active ubiquitin-proteasome system. Journal of Virology. 86(10):5948-52.
  • Cossaboom CM, L. Córdoba, B.A. Dryman, and X.J. Meng. 2011. Hepatitis E Virus in Rabbits, Virginia USA. Emerging Infectious Diseases. 17(11):2047-2049.
  • Pudupakam, R.S., S. P. Kenney, L. Córdoba, Y. W. Huang, B. A. Dryman, T. LeRoith, F.W. Pierson, and X.J. Meng. 2011. Mutational analysis of the hypervariable region of the hepatitis E virus reveals its involvement in the efficiency of viral RNA replication. Journal of Virology. 85:10031–10040.
  • Cordoba L, Y.W. Huang, T. Opriessnig, K.K. Harrall, N.M. Beach, C. Finkielstein, S.U. Emerson, and X.J. Meng. 2011. Three amino acid mutations (F51L, T59A and S390L) in the capsid protein of the hepatitis E virus collectively contribute to virus attenuation. Journal of Virology. 85(11):5338-5349.
  • Cao D, Y.W. Huang, X.J. Meng. 2010. The nucleotides on the stem-loop RNA structure in the junction region of the hepatitis E virus (HEV) genome are critical for virus replication. Journal of Virology. 84(24):13040–13044.
  • Pudupakam RS, Y.W. Huang, P. Billam, S. Ramamoorthy, F.W. Pierson, and X.J. Meng. 2009. Deletions of the hypervariable region (HVR) in open reading frame 1 of hepatitis E virus do not abolish virus infectivity: evidence for attenuation of HVR deletion mutants in vivo. Journal of Virology. 83(1):384-95.
  • Huang YW, Oprissnig T, Halbur PG, and Meng XJ. 2007. Initiation at the third in-frame AUG codon of open reading frame 3 of the hepatitis E virus is essential for viral infectivity in vivo. Journal of Virology. 81:3018-3026.
  • Billam P., F.F. Huang, Z.F. Sun, F.W. Pierson, R.B. Duncan, F. Elvinger, D.K. Guenette, T.E. Toth, and X. J. Meng (2005). Systematic pathogenesis and replication of avian hepatitis E virus in specific-pathogen-free adult chickens. Journal of Virology. 79:3429-37.
  • Huang Y.W., G. Haqshenas, C. Kasorndorkbua, P. G. Halbur, S. U. Emerson, X. J. Meng (2005). Capped RNA transcripts of full-length cDNA clones of swine hepatitis E virus are replication-competent when transfected into Huh7 cells and infectious when intrahepatically inoculated into pigs. Journal of Virology. 79:1552-1558.
  • Emerson SU, Zhang M, Meng X.J., St. Clair M, Nguyen H, Huang Y, and Purcell RH (2001). Recombinant hepatitis E virus genomes infectious for primates: importance of capping and discovery of a cis-reactive element. Proceedings of the National Academy of Sciences USA. 98:15270-15275.
  • Haqshenas, G., H.L. Shivaprasad, P. Woolcock, D. Read, X.J. Meng (2001). Genetic identification and characterization of a novel virus related to human hepatitis E virus from chickens with hepatitis-spleenomegaly syndrome. Journal of General Virology. 82:2449-2462.
  • Kabrane-Lazizi, Y., X.J. Meng, R.H. Purcell, and S.U. Emerson. Evidence that the genomic RNA of hepatitis E virus is capped (1999). Journal of Virology. 73:8848-8850.
  • Meng, X.J., P.G. Halbur, M. Shapiro, S. Govindarajan, J.D. Bruna, I. K. Mushahwar, R.H. Purcell, and S.U. Emerson (1998). Genetic and experimental evidence for cross-species infection by the swine hepatitis E virus. Journal of Virology. 72:9714-9721.
  • Meng, X.J., R.H. Purcell, P.G. Halbur, J.R. Lehman, D.M. Webb, T.S. Tsareva, J.S. Haynes, B.J. Thacker, and S.U. Emerson (1997). A novel virus in swine is closely related to the human hepatitis E virus. Proceedings of the National Academy of Sciences USA 94:9860-9865.

 

We are interested in studying the molecular mechanisms of replication and pathogenesis of coronaviruses with a major focus on developing effective life-saving vaccines, particularly broadly-protective universal coronavirus vaccines. Our current effort focuses on SARS-CoV-2 as well as porcine epidemic diarrhea virus (PEDV), an alphacoronavirus.

Representative Publications

  • Maeda D.L., Tian D., Yu H., Dar N., Rajasekaran V., Meng S., Mahsoub H., Sooryanarain H., Wang B., Heffron C.L., Hassebroek A., LeRoith T., X.J. Meng, and S.L. Zeichner. 2021. Killed whole genome-reduced bacteria surface-expressed coronavirus fusion peptide vaccines protect against disease in a porcine model. Proceedings of the National Academy of Sciences USA. 2021;118(18):e2025622118. doi: 10.1073/pnas.2025622118.
  • Meng XJ, Liang TJ. 2021. SARS-CoV-2 infection in the gastrointestinal tract: fecal-oral route of transmission for COVID-19? Gastroenterology. 2021;160(5):1467-1469.
  • Subramaniam S, Yugo DM, Heffron CL, Rogers AJ, Sooryanarain H, LeRoith T, Overend C, Cao D, Meng XJ. 2018. Vaccination of sows with a dendritic cell-targeted porcine epidemic diarrhea virus S1 protein-based candidate vaccine reduced viral shedding but exacerbated gross pathological lesions in suckling neonatal piglets. Journal of General Virology. 99(2):230-239.
  • Subramaniam S, Cao D, Tian D, Cao QM, Overend C, Yugo DM, Matzinger SR, Rogers AJ, Heffron CL, Catanzaro N, Kenney SP, Opriessnig T, Huang YW, Labarque G, Wu SQ, Meng XJ. 2017. Efficient priming of CD4 T cells by Langerin-expressing dendritic cells targeted with porcine epidemic diarrhea virus spike protein domains in pigs. Virus Research. 227:212-219.
  • Huang YW, A.W. Dickerman, P. Pineyro, L. Li, L. Fang, R. Kiehne, T. Opriessnig, and X.J. Meng. 2013. Origin, evolution, and genotyping of emergent porcine endemic diarrhea virus (PEDV) strains in the United States. mBio. 4(5):e00737-13. doi:10.1128/mBio.00737-13.
  • Sun Z.F., and X.J. Meng. 2004. Antigenic cross-reactivity between the nucleocapsid protein of SARS-coronavirus and polyclonal antisera of antigenic group I animal coronaviruses: Implication for SARS diagnosis. Journal of Clinical Microbiology. 42:2351-2352.

PCV2 remains an economically-important global pathogen causing multisystemic diseases in pigs. Our research has led to the successful development of USDA fully-licensed commercial vaccines that are currently on the global market to protect pigs from PCV2 infection and its associated diseases. We are interested in studying the evolution of the virus in the presence of vaccine-induced immunity, and developing second-generation of PCV2 vaccines.

Representative Publications

  • Opriessnig T, A. Castro, A.K. Karuppanan, P.C. Gauger, P.G. Halbur, S.R. Matzinger, and XJ Meng. 2019. A porcine circovirus 2 (PCV2) b-based experimental vaccine is effective in the PCV2b-Mycoplasma hyopneumoniae coinfection pig model. Vaccine. 37(44):6688-6695.
  • Opriessnig T, Xiao CT, Halbur PG, Matzinger SR, and X.J. Meng. 2017. A commercial porcine circovirus (PCV) type 2a-based vaccine reduces PCV2d viremia and shedding and prevents PCV2d transmission to naïve pigs under experimental conditions. Vaccine. 35(2):248-254.
  • Matzinger SR, Opriessnig T, Xiao CT, Cantazaro N, Beach NM, Slade DE, Nitzel GP, and X.J. Meng. 2016. A chimeric virus created by DNA shuffling of the capsid genes of different subtypes of porcine circovirus type 2 (PCV2) in the backbone of the non-pathogenic PCV1 induces protective immunity against the predominant PCV2b and the emerging PCV2d in pigs. Virology. 498:82-93.
  • Beach NM, S.M. Smith, S. Ramamoorthy, and X.J. Meng. 2011. Chimeric porcine circoviruses (PCV) containing amino acid epitope tags in the C-terminus of the capsid gene are infectious and elicit both anti-epitope tag antibodies and anti-PCV2 neutralizing antibodies in pigs. Journal of Virology. 85:4591-4595.
  • Beach N.M., N.M. Juhan, L. Cordoba, and X.J. Meng. 2010. Replacement of the replication factors of porcine circovirus (PCV) type 2 with those of PCV type 1 greatly enhances viral replication in vitro. Journal of Virology. 84:8986-8989.
  • Fenaux M, T. Opriessnig, P.G. Halbur, F. Elvinger, and X.J. Meng (2004). Two amino acid mutations in the capsid protein of type 2 porcine circovirus (PCV2) enhanced PCV2 replication in vitro and attenuated the virus in vivo. Journal of Virology. 78:13440-13446.
  • Lekcharoensuk P, I. Morozov, P.S. Paul, N. Thangthumniyom, W. Wajjawalku, and X.J. Meng (2004). Epitope mapping of the major capsid protein of type 2 porcine circovirus (PCV2) using chimeric PCV1 and PCV2 viruses. Journal of Virology. 78:8135-8145.
  • Fenaux M, T. Opriessnig, P.G. Halbur, F. Elvinger, and X.J. Meng (2004). A chimeric porcine circovirus (PCV) with the immunogenic capsid gene of the pathogenic PCV2 cloned into the genomic backbone of the non-pathogenic PCV1 induces protective immunity against PCV2 infection in pigs. Journal of Virology. 78:6297-6303.
  • Fenaux, M., T. Opriessnig, P.G. Halbur, X.J. Meng (2003). Immunogenicity and pathogenicity of the chimeric infectious DNA clones between pathogenic type 2 porcine circovirus (PCV2) and non-pathogenic PCV1 in weaning pigs. Journal of Virology. 77:11232-11243.
  • Fenaux, M., P.G. Halbur, G. Haqshenas, R. Royer, P. Nawagitgul, M. Gill, T.E. Toth, and X.J. Meng (2002). The cloned genomic DNA of the type-2 porcine circovirus (PCV-2) is infectious when injected into the liver and lymph nodes of SPF pigs: characterization of clinical course, virus distribution and pathological lesions. Journal of Virology. 76:541-551.

PRRSV arguably is the most economically-important global pathogen causing reproductive diseases in sows and respiratory diseases in young piglets worldwide. Our group has done several seminal work on PRRSV including the cloning and partial sequencing of the first U.S. strain of PRRSV, proposing the existence of two different genotypes of PRRSV, development of candidate PRRSV vaccines and construction of DNA-launched infectious clone, etc. We are interested in developing second-generation of vaccines against PRRSV, and delineating the immune correlates of protection.

Representative Publications

  • Cao QM, D. Tian, C.L. Heffron, S. Subramaniam, T. Opriessnig, D.L. Foss, J.G. Calvert, and X.J. Meng. 2019. Cytotoxic T lymphocyte epitopes identified from a contemporary strain of porcine reproductive and respiratory syndrome virus enhance CD4+CD8+ T, CD8+ T, and gamma delta T cell responses. Virology. 538:35-44.
  • Cao QM, Ni YY, Cao D, Tian D, Yugo DM, Heffron CL, Overend C, Subramaniam S, Rogers AJ, Catanzaro N, LeRoith T, Roberts PC, Meng XJ. 2018. Recombinant porcine reproductive and respiratory syndrome virus expressing membrane-bound IL-15 as immunomodulatory adjuvant enhances NK and γδ T cell responses and confers heterologous protection. Journal of Virology. pii: JVI.00007-18. doi: 10.1128/JVI.00007-18.
  • Cao QM, Subramaniam S, Ni YY, Cao D, and X.J. Meng. 2016. The non-structural protein Nsp2TF of porcine reproductive and respiratory syndrome virus down-regulates the expression of Swine Leukocyte Antigen class I. Virology. 491:115-124.
  • Tian D, Ni YY, Zhou L, Opriessnig T, Cao D, Piñeyro P, Yugo DM, Cao Q, Overend C, Heffron CL, Halbur PG, Pearce DS, Calvert JG, and Meng XJ. 2015. Chimeric porcine reproductive and respiratory syndrome virus containing shuffled multiple envelope genes confers cross-protection in pigs. Virology. 485:402-413.
  • Ni YY, T. Opriessnig, L. Zhou, D. Cao, Y.W. Huang, P.G. Halbur, and X.J. Meng. 2013. Attenuation of porcine reproductive and respiratory syndrome virus by molecular breeding of the virus envelope genes from genetically divergent strains. Journal of Virology. 87:304-313.
  • Opriessnig T., P.G. Halbur, K.J. Yoon, R.M. Pogranichniy, E.M. Vaughn, K.M. Harmon, R.Evans, K.F. Key, F.J. Pallares, P. Thomas, X.J. Meng (2002). Comparison of molecular and biological characteristics of a modified live PRRSV vaccine (RespPRRS/Repro™), the parent strain of the vaccine (ATCC VR2332), ATCC VR2385, and two recent field isolates of PRRSV. Journal of Virology. 76:11837-11844.
  • Meng, X.J., P.S. Paul, I. Morozov, and P.G. Halbur (1996). A nested set of six or seven subgenomic mRNAs is formed in cells infected with different isolates of porcine reproductive and respiratory syndrome virus. Journal of General Virology. 77:1265-1270.
  • Meng, X.J., P.S. Paul, and P.G. Halbur (1994). Molecular cloning and nucleotide sequencing of the 3' terminal genomic RNA of porcine reproductive and respiratory syndrome virus. Journal of General Virology. 75:1795-1801.

Torque teno viruses (TTVs) are single-stranded small DNA viruses with a circular genome. TTVs have been identified in humans and other animals including pigs. The Torque teno sus viruses (TTSuV1 and TTSuV2) have not yet been definitively linked to a disease. We are interested in understanding the molecular mechanism of TTSuV replication.

Representative Publications

  • Meng XJ, Huang YW. 2021. Circoviridae and Anelloviridae. In: Fields Virology, 7th Edition. David M. Knipe and Peter M. Howley (eds). Lippincott Williams & Wilkins, Philadelphia, PA. pp197-211.
  • Huang YW, A.R. Patterson, T. Opriessnig, B.A. Dryman, A. Gallei, K.K. Harrall, E.M. Vaughn, M.B. Roof, and X.J. Meng. 2012. Rescue of a porcine anellovirus (Torque teno sus virus 2) from cloned genomic DNA in pigs. Journal of Virology. 86:6042-6054.
  • Huang YW, K.K. Harrall, B.A. Dryman, T. Opriessnig, E.M. Vaughn, M.B. Roof, and X.J. Meng. 2012. Serological profile of Torque teno sus virus species 1 (TTSuV1) in pigs and antigenic relationships between two TTSuV1 genotypes (1a and 1b), between two species (TTSuV1 and 2), and between porcine and human anelloviruses. Journal of Virology. 86(19):10628-10639.
  • Huang YW, Harrall KK, Dryman BA, Beach NM, Kenney SP, Opriessnig T, Vaughn EM, Roof MB, and X.J. Meng. 2011. Expression of the putative ORF1 capsid protein of Torque teno sus virus 2 (TTSuV2) and development of Western blot and ELISA serodiagnostic assays: correlation between TTSuV2 viral load and IgG antibody level in pigs. Virus Research. 158:79-88.
  • Huang YW, Y.Y. Ni, B.A. Dryman, and X.J. Meng. 2010. Multiple infection of porcine Torque teno virus in a single pig and characterization of the full-length genomic sequences of four U.S. prototype PTTV strains: Implication for genotyping of PTTV. Virology. 396:289-297.

 

Current Lab Members

X.J. Meng, MD, PhD

University Distinguished Professor

Headshot of Menuka Bhandari.

Menuka Bhandari, PhD

Postdoctoral Associate
menukab24@vt.edu

Headshot of Lynn Heffron.

C. Lynn Chandler, BS

Lab Manager

Headshot of Hassan Mahsoub.

Hassan Mahsoub, PhD

Senior Research Associate

Debin Tian, DVM, PhD

Research Scientist

Headshot of Alex Wheatley.

Alex Wheatley, BS

Research Assistant
awheatley@vt.edu

Headshot of Kush Yadav.

Kush Yadav, DVM, PhD

Postdoctoral Associate

 

Alumni

  • Anna Hassebroek, PhD (awarded in Fall 2023)
  • Nicholas Catanzaro, PhD (awarded in Fall 2019)
  • Danielle M. Yugo, PhD (awarded in Fall 2018)
  • Qian M. Cao, PhD (awarded in Fall 2017)
  • B.A. Venkatachalam, M.S. (awarded in Spring 2016)
  • Pablo Pineyro, PhD (awarded Fall 2015)
  • Caitlin Cossaboom, PhD (awarded in Spring 2014)
  • Yanyan Ni, PhD (awarded in Fall 2013)
  • Brent Sanford, PhD (awarded in Summer 2012)
  • Sara Smith, M.S. (awarded in Summer 2011)
  • R.S. Pudupakam, PhD (awarded in Spring 2011)
  • Alicia Feagins, PhD (awarded in Fall 2010)
  • Jenn Gillespie, M.S. (awarded in May 2009)
  • Padma Billam, PhD (awarded in Spring 2007)
  • Nicole McKeown, Ph.D. (awarded in Spring 2007)
  • Kijona F. Key, PhD (awarded in Spring 2007)
  • Zhi-Feng Sun, PhD (awarded in Spring 2005)
  • Fang-Fang Huang, PhD (awarded in Fall 2004)
  • Kerri Cooper, M.S. (awarded in Summer 2004)
  • Martijn Fenaux, PhD (awarded in Spring 2004)
  • Trevor Williams, M.S. (awarded in Spring 2001)
  • 2019-2024: Bo Wang, PhD (Robert Koch Institute, Germany)
  • 2015-2022: Harini Sooryanarain, PhD (Univ of Pune, India)
  • 2011-2019: Sakthivel Subramaniam, PhD (Univ of Nebraska-Lincoln)
  • 2013-2018: Adam Rogers, PhD (Univ of Nebraska-Lincoln)
  • 2013-2017: Chris Overend, PhD (Univ of Connecticut, Storrs)
  • 2012-2017: Shannon Matzinger, PhD (Uinv of California, Davis)
  • 2008-2017: Dianjun Cao, PhD (Chinese Academy of Agricultural Sci, Beijing)
  • 2008-2016: Scott Kenney, PhD (Penn State Univ)
  • 2014-2015: Heng Wang, DVM, PhD (Northeast Agricultural University, China)
  • 2013-2015: Mary Etna Haac, PhD (Virginia Tech)
  • 2011-2013: Lei Zhou, PhD (China Agriculture University, Beijing)
  • 2010-2012: Yogesh Karpe, PhD (Natl Inst of Virology, Pune, India)
  • 2003-2012: Yao-Wei Huang, PhD (Zhejiang University, China)
  • 2008-2011: Laura Cordoba, PhD (University of Madrid, Spain)
  • 2008-2011: Nathan Beach, PhD (Virginia Tech)
  • 2010: Yumin Zhu, PhD (Nanjing Agricultural Univ, China)
  • 2009-2010: Hyuk-Moo Kwon, DVM, PhD (University of Georgia)
  • 2008: Bibianna Peralta, DVM, PhD (University of Barcelona, Spain)
  • 2006-2008: Sheela Ramamoorthy, PhD (Virginia Tech)
  • 2004-2007: Fang-Fang Huang, DVM, PhD (Virginia Tech)
  • 2003: Margarita Martin, DVM, PhD (Universitat Autonoma de Barcelona)
  • 2002: B.E. Fulton, PhD (University of California-Davis)
  • 2000-2002: Gholamreza Haqshenas, PhD (University of Sydney, Australia)
  • 2020-2021: Guillermo Raimundi Rodríguez (Univ of Puerto Rico, PREP student)
  • 2017: Meredith Dove (VT Microbiology major)
  • 2015-2016: Herbert Portillo (VT PREP student)
  • 2011-2015: Jacquelyn Wentworth (VTCSOM medical student)
  • 2010: Michelle Walker (VT PREP student)
  • 2009: Carmen Ledesma (NIH T35 trainee)
  • 2006-2007: Christine George (VT Biology major, honor student research)
  • 2007: Christina Connor (VT veterinary medicine), preceptorship
  • 2005-2006: Alicia Feagins (Mercer University, PREP student)
  • 2004-2005: Jenn Gillespie (VT Animal Sciences major, honor student research)
  • 2003: Erin Sturgill (VT Veterinary Medicine major)
  • 2002-2003: Leslie Wahlgren (VT biology major)
  • 2002: Alan Dunlop (Biology major, ISEP exchange student from Napier Univ, Scotland)
  • 2001-2002: Nicole McKeown (VT Biology major)
  • 2000: Amy Weaver (VT Biology major)
  • 2000: Kijona Key (UVA Biology major, MOAP student)
  • 1999-2000: M. Ben Potters (VT Biochemistry major)
  • 1999: Martijn Fenaux (VT Biology major)
  • 2012-2013: Chandra Shrestha, PhD (Univ of Philippines), Lab Specialist
  • 2007-2012: Barbara Dryman, B.S. (Virginia Tech), Lab Specialist
  • 2009-2010: Nicole Plaskon, B.S., M.S. (Virginia Tech), Research Associate
  • 2009-2010: Kylie Harrell, B.S. (Univ of Missouri-St Louis), Lab Specialist
  • 2000-2007: Denis Guenette, B.S. (University of New Hampshire), Lab Specialist
  • 2005-2007: Jenn DiCristina, B.S. (Virginia Tech), Lab Specialist
  • 1999-2001: Crystal Gilbert, B.S. (Radford University), Lab Specialist
Headshot of X.J. Meng

Xiang-Jin “X.J.” Meng is a University Distinguished Professor of Molecular Virology with joint appointments in the Virginia-Maryland College of Veterinary Medicine and Virginia Tech Carilion School of Medicine. 

Dr. Meng is an elected Member of the National Academy of Sciences, an elected Fellow of the National Academy of Inventors, an elected Fellow of the American Academy of Microbiology, and an elected Fellow of the American Association for the Advancement of Science. He is the recipient of NIH MERIT Award, recipient of Virginia Tech Lifetime Achievement Award for Innovation, recipient of the Inaugural Lorraine J. Hoffman Graduate Alumni Award from Iowa State University, and recipient of the 2017 State Council of Higher Education for Virginia (SCHEV) Outstanding Faculty Award.

He received his PhD in Immunobiology from Iowa State University (Ames, IA) and completed his postdoctoral training at NIAID, NIH (Bethesda, MD). Meng has been a faculty member at Virginia Tech since 1999. He is the founding director of the Virginia Tech Center for Emerging, Zoonotic and Arthropod-borne Pathogens (CeZAP), and also served as the Interim Executive Director of the Fralin Life Sciences Institute at Virginia Tech.

Dr. Meng currently serves as Editor or Editor-in-Chief for four international journals (PNAS, mBio, Virus Research, and Veterinary Microbiology).

*The below information has been filtered and selected.

PhD, Immunobiology, 1995
Department of Microbiology, Immunology and Preventive Medicine
College of Veterinary Medicine
Iowa State University
Ames, Iowa

MS, Microbiology and Immunology, 1988
Hubei Medical College
Hubei, PRC

MD, Medicine, 1985
Binzhou Medical College
Binzhou, Shandong, PRC

2013-present
University Distinguished Professor of Molecular Virology
Virginia-Maryland College of Veterinary Medicine
Virginia Tech
Blacksburg, VA

2011-present
Professor of Internal Medicine
Department of Internal Medicine
Virginia Tech Carilion School of Medicine
Roanoke, VA

Dec. 2021-Nov. 2022
Interim Executive Director
Fralin Life Sciences Institute
Virginia Tech
Blacksburg, VA

July 2020-Aug. 2022
Founding Director
Center for Emerging, Zoonotic and Arthropod-borne Pathogens (CeZAP)
Virginia Tech
Blacksburg, VA

2006-2016, 2019-Present
Director

Virginia Tech NIH T32 Post-DVM Graduate Training Program 

2006-2008
Director

DVM/PhD Dual Degree Graduate Program
Virginia-Maryland College of Veterinary Medicine
Virginia Tech
Blacksburg, VA

2007-2013
Professor of Molecular Virology
Department of Biomedical Sciences and Pathobiology
Virginia-Maryland College of Veterinary Medicine
Virginia Tech
Blacksburg, VA

2003-2007
Associate Professor of Molecular Virology

Department of Biomedical Sciences and Pathobiology
Virginia-Maryland College of Veterinary Medicine
Virginia Tech
Blacksburg, VA

1999-2003
Assistant Professor of Molecular Virology

Department of Biomedical Sciences and Pathobiology
Virginia-Maryland College of Veterinary Medicine
Virginia Tech
Blacksburg, VA

1998-1999
Senior Staff Fellow, Molecular Hepatitis Section

Laboratory of Infectious Diseases
National Institute of Allergy and Infectious Diseases
National Institutes of Health
Bethesda, MD

1995-1998
John E. Fogarty Visiting Scientist, Hepatitis Viruses Section

Laboratory of Infectious Diseases
National Institute of Allergy and Infectious Diseases
National Institutes of Health
Bethesda, MD

1991-1995
Graduate Research Assistant

Department of Microbiology, Immunology, and Preventive Medicine
College of Veterinary Medicine
Iowa State University
Ames, IA

1988-1991
Research Associate

Institute of Basic Medical Sciences
Shandong Academy of Medical Sciences
Shandong, PRC

1985-1988
Graduate Research Assistant

Hubei Medical College
Hubei, PRC

1984-1985
Medical Intern

Affiliated Hospital of Binzhou Medical College
Shandong, PRC

  • 2024: Recipient, NIH MERIT Award
  • 2023: Recipient, Virginia Tech Lifetime Achievement Award for Innovation. April 2023.
  • 2022: Recipient, Virginia Tech Commercialization Champion Award, April 2022.
  • 2021: Fellow, American Association for the Advancement of Science, elected to AAAS Fellow in Dec 2021
  • 2021: Recipient, The Dr. Mikhail Balayan Medal for Contribution to the Study of Hepatitis E.
  • 2019: Recipient, The Inaugural Lorraine J. Hoffman Alumni Award, Iowa State University.
  • 2017: Recipient, 2017 Outstanding Faculty Award by State Council of Higher Education for Virginia (SCHEV).
  • 2016: Member, U.S. National Academy of Sciences, elected to NAS in May 2016.
  • 2014: Fellow, National Academy of Inventors, elected to NAI in December 2014.
  • 2013: Recipient of University Distinguished Professor title, a pre-eminent and lifetime title bestowed by the University Board of Visitors.
  • 2012: Fellow, American Academy of Microbiology, elected to the AAM in February 2012.
  • 2008: Recipient, Inaugural Fralin Life Science Institute Senior Faculty Fellow Award.
  • 2008: Recipient, Honorary Diplomat, American College of Veterinary Microbiologists.
  • 2008: Recipient, the 2008 Alumni Award for Research Excellence, Virginia Tech.
  • 2008: Honor, Thomson Scientific ranked Meng in the top 1% highly-cited scientists in the field of Microbiology based on total citations from January 1997 to August 2007.
  • 2007: Recipient, The 2007 Pfizer Award for Research Excellence, Pfizer Inc.
  • 2003, 2009: Recipient, “Outstanding Editorial Board Member”, Journal of Clinical Microbiology
  • 2002: Recipient, Clifton Garvin Award (“faculty representing VA Tech’s future”), VA Tech.
  • 2001:  Recipient, The 2001 Pfizer Award for Research Excellence, Pfizer Inc.
  • 1997:  Recipient, NIH Fellows Award for Research Excellence, NIH, Bethesda, Maryland.
  • 1996: Recipient, The Zaffarano Prize for Research Excellence, Iowa State University, Ames, IA.
  • 2023-2024: Member of the World Health Organization (WHO)'s Prioritization Advisory Committee and Chair of the Hepeviridae Subcommittee to prioritize pathogens of epidemic and pandemic significance, WHO's World Health Emergencies and the R&D Blueprint. 2023-2024.
  • 2023-2024: Member, Joint Food and Agriculture Organization (FAO) of United Nation / World Health Organization (WHO) Expert Committee on microbiological risk assessment of viruses in foods. Part 1: food attribution, analytical methods, and indicators. September 18-22, 2023, FAO Headquarter, Rome, Italy.   Part 2: Prevention and Intervention Measures.  February 12-16, 2024, WHO Headquarter, Geneva, Switzerland.
  • 2023 - present: Discipline Chair, National Academy of Sciences (NAS) Section 61's Veterinary and Wildlife Science and Health discipline.
  • 2019-present: Board of Directors, Virginia Tech Intellectual Properties, Inc.
  • 2016-present: Board of Directors, Virginia Academy of Sciences, Engineering, and Medicine (VASEM).
  • 2012-present: member, Hepeviridae Subcommittee, Intl Committee on Taxonomy of Viruses.
  • 2022-2024: Member of the Advisory Council, Iowa State University College of Veterinary Medicine.
  • 2022: Chair, New Member Selection Committee, Virginia Academy of Sciences, Engineering, and Medicine (VASEM)
  • 2021: Acting Discipline Chair, NAS Section 61 Veterinary and Wildlife Science and Health Discipline, National Academy of Sciences (NAS).
  • 2020-2022: NAS Council Designee, Class Membership Committee, National Academy of Sciences.
  • 2017: Chair, Summit on Emerging Infections and Preparedness at the National Academy of Sciences, Washington DC. Virginia Academy of Science, Engineering and Medicine.
  • 2016: Member, Fellows Advisory Committee of the National Academy of Inventors.
  • 2012-2015: Member, Selection committee for ASM’s "Merck Irving S. Sigal Memorial Award".
  • 2015: USDA-NIFA Liaison for 1890 Institutions faculty.
  • 2011: Chair, USDA-ARS Animal Health National Program NP 103 Panel I – Swine (2011).
  • 2011: Chair, Novel Vaccine and Vaccination Strategy Workshop. Dec 2, 2011. Chicago, IL.
  • 2011-2016: Co-Chair, local planning committee, 2016 Annual Meeting of Am Soc for Virology.
  • 2011: Co-Chair of “Vaccine and Antiviral” Session and Member of the Program Committee, XIIth Intl Nidovirus Symposium, Grand Traverse Resort & Spa, MI.
  • 2009-2012: Chair, USDA NC-229 committee on emerging viral diseases of swine.
  • 2009-2011: Chair, The 2010 and 2011 International PRRS Symposia, Chicago, IL.
  • 2010-2015: Member, Scientific Working Group (SWG), NIH-NIAID Bioinformatics Resource Centers (BRC)’s Viral Pathogen Database and Analysis Resource (ViPR).
  • 2010: Expert consultant, FDA Type C committee meeting on Abbott’s Creon Pancrelipase, May.
  • 2010: Expert consultant, FDA hearing by the Vaccine and Related Biological Products Advisory Committee on GSK’s Rotarix vaccine. Gaithersburg, MD. May 7, 2010.
  • 2008-2009: Chair, Program Committee, International PRRSV Symposiums. Chicago, IL.
  • 2007-2009: Secretary, U.S. Department of Agriculture NC-229 committee on PRRSV.
  • 2005-2011: Chair, Hepeviridae Subcommittee, Intl Committee on Taxonomy of Viruses.
  • 2006-2007: Member, National Pork Board Planning Committee on PCV2 associated diseases.
  • 2016-present: Editor (2016-present) and Board member (2020-present), Proc Natl Acad Sci USA
  • 2016-present: Editor, Virus Research
  • 2014-present: Editor-in-Chief, Veterinary Microbiology
  • 2013-present: Editor, mBio
  • 2015-2021: Guest Editor, PLOS Pathogens
  • 2012-2021: Editor, Animal Health Research Reviews
  • 2012-2016: Editor, PloS One
  • 2019-present and 2011-2015: Emerging Microbes and Infections
  • 2016-present: Virology
  • 2017-2022: Journal of Virology
  • 2012-2016: Virus Research
  • 2009-2013: Veterinary Microbiology
  • 2011: Chairperson of USDA-ARS Animal Health National Program NP 103 Panel I.
  • 2009: Rapporteur of 7th Framework Programme for Research - European Union Panel on PRRS.
  • 2008: Chair, NIH Special Emphasis Panel IDM-B (15) Study Section.
  • 2009-2013: Permanent member, NIH Virology-A Study Section (VIRA).
  • 2004-2008: Permanent Member, NIH Drug Discovery&Antimicrobial Resistance Study Section.
  • 2007: Member, NIH-NCRR Comparative Medicine Special Emphasis Panel CMRC-03.
  • 2002-2003: Member of NIH Comparative Medicine Study Section.
  • 2004-2005: Member, NIH Special Emphasis Panels ZRG1 IDM-N 90S; ZRG1DDR(01), and ZRG1 DDR01Q.
  • 2002-2003: Member and Site visit team, NIH-NCRR Comparative Medicine Study Section.
  • 1999-2006: Member, Virology Panel, U.S. Military Infectious Diseases Research Program.
  • 1999-2000: Chair, Viral Hepatitis Annual Reports Panel, U.S. Military Infectious Dis Program.

Received a total of 133 research grant awards from NIH, USDA, NSF, private sectors, and non-profit organization as a PI (60 grants, $26,161,225) or Co-PI/Co-I/Mentor (73 grants, $55,449,023).

Patents: Inventor of 22 awarded U.S. patents, and 17 pending U.S. patents on vaccines.

Commercial products: Meng lab’s research led to the development of Fostera™ PCV (Suvaxyn® PCV2 One DoseTM vaccine, Relsure® PCV), the first USDA-fully licensed vaccine against porcine circovirus 2 (PCV2), which has been on global market since 2006. Also, the Fostera™ PCV MH, a bivalent commercial vaccine against both PCV2 (from Meng lab’s invention) and M. hyopneumonia (from Zoetis), has also been on the global market since 2014. 

Served as major professor for 21 graduate students, a member of Graduate Advisory Committee for 66 graduate students, mentor for 17 undergraduate students, and mentor for 26 postdoctoral fellows. Meng’s graduate students and postdoc fellows won >50 national and university awards.

Course Leader

  • 2008-2017: Molecular Virology (BMVS5624), course leader;
  • 2005-2017: Emerging Infectious Diseases-I (VM9085/BMVS5005), course leader;
  • 2005-2017: Emerging Infectious Diseases-II (VM9086/BMVS5006), course leader;
  • 2003-2006: Medical Virology (VCOM), course leader.

Course Participant

  • 2018-present: Instructor, Molecular Virology (BMVS 5624). Contributing 5 lectures/yr
  • 2018-present: Instructor, Emerging Infectious Diseases (VM9085/BMVS5005). Contributing 1 lecture/yr
  • 2016-present: Instructor, Dealing with Threat (VM8174). Contributing 3 lectures/yr
  • 2015, 2017-2019: Guest lecturer, Immunity and Infectious Diseases (TBMH5054): Vaccine (2-hr lecture/yr); Virology (2-hr lecture/yr since 2019).
  • 2011-2012: Research Domain Core Competency: Grant Writing, VT Carillion School of Medicine. Each spring semester (1 lecture).
  • 2011-2017: Zoonoses and Communicable Diseases Common to Humans and Animals (PHS 5304).  Each Fall semester (4 lectures).
  • 2002-2015: Veterinary Virology (VM8124/BMVS5054) (responsible for one-third of the lectures, total 9 lectures per year).
  • 2024: Invited Participant, White House Roundtable on Emerging Technologies for Preventing Health Emergencies. WHite House Office of Science and Technology Policy. August, 2024, Washington, DC.
  • 2024: Invited Keynote Speaker, International PRRS Symposium (IPRRSS 2024). Title: Novel vaccine candidates against porcine epidemic diarrhea vrus. August 6-9, 2024, Yantai, China.
  • 2024: Invited Seminar Speaker, Department of Microbiology, Harvard Medical School, Boston MA. Title: Hepatitis E Virus: Emerging and Zoonotic Virus Infection Beyond the Liver. March 20, 2024. Boston, MA.
  • 2024: Invited Seminar Speaker, Keck School of Medicine, University of Southern California, Los Angeles, CA. Title: Hepatitis E Virus: an emering zoonotic virus with extrahepatic disease manifestation. Feb. 28, 2024, Los Angles, CA.
  • 2023: Invited Keynote Speaker, North American PRRS and International Conference of Swine Viral Diseases. Title: Novel Vaccines for Porcine Epidemic Diarrhea Virus. Chicago, Il, December 1, 2023.
  • 2023: Invited Keynote Speaker, University of Georgia College of Veterinary Medicine Annual Research Symposium. Title: One Health Approach for Emerging and Zoonotic Viral Diseases. October 8, 2023, Athens, GA.
  • 2023: Invited Seminar Speaker, Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston MA. Title: Hepatitis E virus-associated fulminant hepatic failure during pregnancy and neurological sequelae. August 24, 2023, Boston, MA.
  • 2021: Charles Valentine Riley Memorial Lecturer. Presented by AAAS, World Food Prize, and Riley Foundation. Title: One Health Perspectives on Emerging Zoonotic Diseases. Washington DC, Sept 30, 2021.
  • 2020: Invited Forum Speaker, The 2020 World Knowledge Forum: COVID-19 and New Economic Normal. Title: Root cause of pandemics and lessons learned from animal coronavirus vaccines. Seoul, South Korea.
  • 2019: Invited Symposium Speaker, Keystone Symposia - Positive-Strand RNA Viruses. Title: Hepatitis E virus: Animal reservoirs and cross-species infection. June 9-13, 2019, Kerry, Ireland.
  • 2019: The Inaugural Michael Murtaugh Memorial Lecturer. University of Minnesota, Minneapolis, MN. Title: Novel vaccines against porcine reproductive and respiratory syndrome virus. Feb. 6, 2019. Minneapolis, MN.
  • 2018: Keynote Speaker, 25th International Pig Veterinary Society (IPVS) Congress. Title: Emerging and zoonotic viruses in swine: swine hepatitis E virus as an example. June 12-15, 2018, Chongqing, China.
  • 2017: Dr. K.-T. Jeang Memorial Lecturer. Title: Hepatitis E virus: mechanism of cross-species and zoonosis. National Institutes of Health. May 2017,  Bethesda, MD.
  • 2017:  Keynote Speaker, Ohio State University College of Veterinary Medicine 2017 Research Day Symposium. Title: Hepatitis E virus: animal reservoirs and cross-species infection. April 6, 2017. Columbus, OH.
  • 2016: Special NAS Inductee Lecturer. USDA Program Directors Meeting. Title: Novel veterinary vaccines: PRRSV as an example.  Dec. 2, 2016. Chicago, IL.
  • 2016: Invited Seminar Speaker. Rockefeller University. Title: Hepatitis E virus: mechanism of cross-species infection.  Nov. 1, 2016. New York, NY.
  • 2015: The Maurice Hilleman Merck Research Laboratories Lecturer, 34th Annual Meeting of the American Society for Virology. Title: The ever-expanding host range of hepatitis E virus and cross-species infection. July 11-15. London, Ontario, Canada. 
  • 2014: Invited Symposium Speaker, International Symposium on Vaccines Against Antigenically Variable Viruses (VAAVV). Title: Novel Vaccines against Heterologous Strains of PRRSV. June 18 to 20, 2014. Ames, IA.
  • 2012: Invited Symposium Speaker, 2012 International PRRS Symposium and National Swine Improvement Federation Conference.  Title: Molecular breeding of PRRSV for novel vaccine development.  November 29-30, 2012.  Kansas City, MO.
  • 2012: Invited Keynote Speaker, Komipharm Symposium - 22nd Intl Pig Veterinary Society Congress. Title:  Novel PRRSV vaccines and control strategy. June 10, Jeju, Korea.
  • 2012: Invited Speaker, FAIR 2012 National Forum. Title: One Health Research: Zoonosis and Cross-species Infection. March 4-6, 2012, Arlington, VA.
  • 2011: Invited Symposium Speaker, 6th Intl Symposium on Emerging and Re-emerging Pig Diseases. Title: Emerging Viruses in Swine. June 12-15, 2011. Barcelona, Spain.
  • 2010: Invited Seminar Speaker, U.S. Food and Drug Administration (FDA) Center for Biological Evaluation and Research’s Division of Viral Products Seminar Series. Title: Porcine circovirus replication and pathogenesis. Nov 18, 2010, Bethesda, MD.
  • 2010: Invited Symposium Keynote Speaker, HEV and HAV Symposium of the United States-Japan Cooperative Medical Science Program. Title: Update on hepatitis E virus replication and pathogenesis. Sept 7-9, 2010, Yokohama, Japan.
  • 2009: Frank Ramsey Lecturer, Iowa State University. Title: Hepatitis E virus: Zoonotic risk and food safety. Nov 11-13, Ames, Iowa.
  • 2009: Invited Plenary Speaker, 13th International Symposium on Viral Hepatitis and Liver Disease. Title: Hepatitis E Virus as a Zoonosis. Washington DC, March 20-24.
  • 2007: Invited Keynote Speaker, International Symposium on PRRS and PRRS related diseases: Prevention and Control Strategies. Nov. 30-Dec. 1. Chicago, IL.
  • 2005: Invited Conference Speaker.  M.E. Ensminger International Conference on Animal Diseases. Title: Molecular pathogenesis and vaccine development against type 2 porcine circovirus and PMWS.  October 10-14.  Hangzhou, China.
  • 2005: Invited Keynote Speaker. International Conference on Animal Circoviruses and Associate Diseases. Title: Molecular biology of porcine circovirus: epitope mapping and genetic determinants for virulence. Sept 11-13. Belfast, Ireland.
  • 2005: Invited Symposium Speaker. International Symposium on Hepatitis E Virus. Title: Biology of animal strains of hepatitis E viruses. Feb. 17-18. New Delhi, India.
  • 2003: Invited Honorable Special Luncheon Seminar Speaker and Minophagen Lecturer, 89th Annual Meeting of the Japanese Society of Gastroenterology. Title: Recent advance in hepatitis E research. April 24-26. Tokyo, Japan.

 

Meng's Google Scholar profile [>38,213 total citations; h-index = 102; i10-index=296]

362. Bo Wang, S. Subramaniam, D. Tian, H.M. Mahsoub, C.L. Heffron, and X.J. Meng. 2024. Phosphorylation of Ser711 residue in the hypervariable region of zoonotic genotype 3 hepatitis E virus is important for virus replication.  mBio. 2024 Oct 8:e0263524. doi: 10.1128/mbio.02635-24.

361. Meng XJ, Huang YW. 2024. Chapter 67: Circoviridae and Anelloviridae. In: Fields Virology, 8th Edition. David M. Knipe and Peter M. Howley (eds). Lippincott Williams & Wilkins, Philadelphia, PA. In Press.

360. Segalés J, Benfield D, Chang C-Y, Saif LJ, Jung K, Denner J, Hesse RA, and X.J. Meng. 2024. Chapter 41. Miscellaneous Viral Infections.  In: Jianqiang Zhang, Jeffrey J. Zimmerman, (eds): Diseases of Swine, 12th Edition. John Wiley & Sons Ltd. In Press.

359. Gerber PF, Cao D, Xiao C-T, Chen Q, Lager K, Bosch BJ, Meng XJ, Halbur PG and Opriessnig T. 2023. Failure to experimentally infect 10 days-old piglets with a cell culturepropagated infectious stock of a classical genotype 1a porcine epidemic diarrhea virus. Frontiers in Veterinary Science. 2023;10:1279162. doi: 10.3389/fvets.2023.1279162.

358. Hassebroek, A.M., and X.J. Meng. 2023. Veterinary coronavirus vaccines: successes, challenges & lessons learned for SARS-CoV-2 control.  Vaccine Insights. 2023; 2(8), 259–277. DOI: 10.18609/vac.2023.039. 

357. Mah JK, Keck M, Chu DY, Sooryanarain H, Sahoo MK, Lau P, Huang C, Weber J, Belanger GA, Keck Z, Shan H, Meng XJ, Foung SKH, Pinsky BA, Pham TD. 2023. Hepatitis E virus seropositivity in an ethnically diverse community blood donor population.  Vox Sang. 2023 Jun 27. doi: 10.1111/vox.13487.

356. Mahsoub HM, Heffron CL, Hassebroek AM, Sooryanarain H, Wang B, LeRoith T, Rodríguez GR, Tian D, and X.J. Meng. 2023. Fetal Loss in Pregnant Rabbits Infected with Genotype 3 Hepatitis E Virus Is Associated with Altered Inflammatory Responses, Enhanced Virus Replication, and Extrahepatic Virus Dissemination with Positive Correlations with Increased Estradiol Level. mBio. 2023 Mar 20:e0041823. doi: 10.1128/mbio.00418-23. 

355. Wang B, Mahsoub HM, Li W, Heffron CL, Tian D, Hassebroek AM, LeRoith T, and X.J. Meng.  2023. Ribavirin Treatment Failure-Associated Mutation, Y1320H, in the RNA-Dependent RNA Polymerase of Genotype 3 Hepatitis E Virus (HEV) Enhances Virus Replication in a Rabbit HEV Infection Model.  mBio. 2023:e0337222. doi: 10.1128/mbio.03372-22.

354. Hassebroek AM, Sooryanarain H, Lynn Heffron C, Hawks SA, LeRoith T, Cecere TE, Stone WB, Walter D, Mahsoub HM, Wang B, Tian D, Ivester HM, Allen IC, Auguste AJ, Duggal NK, Zhang C, and X.J. Meng. 2023. A hepatitis B virus core antigen-based virus-like particle vaccine expressing SARS-CoV-2 B and T cell epitopes induces epitope-specific humoral and cell-mediated immune responses but confers limited protection against SARS-CoV-2 infection. Journal of Medical Virology. 2023 Jan 19. doi: 10.1002/jmv.28503.

353. Sooryanarain H, Heffron CL, Mahsoub HM, Hassebroek AM, Wang B, Tian D, Ahmed SA, and X.J. Meng. 2022. Modulation of SOCS3 Levels via STAT3 and Estrogen-ERαp66 Signaling during Hepatitis E Virus Replication in Hepatocellular Carcinoma Cells. Journal of Virology. 2022 Sep 14:e0100822. doi: 10.1128/jvi.01008-22.

352. Purdy MA, Drexler JF, X.J. Meng, Norder H, Okamoto H, Van der Poel WHM, Reuter G, de Souza WM, Ulrich RG, Smith DB. 2022. ICTV Virus Taxonomy Profile: Hepeviridae 2022. Journal of General Virology. 2022;103(9). doi: 10.1099/jgv.0.001778.

351. Bo Wang, Tian D, Sooryanarain H, Mahsoub HM, Heffron CL, Hassebroek AM, and X.J. Meng. 2022. Two mutations in the ORF1 of genotype 1 hepatitis E virus enhance virus replication and may associate with fulminant hepatic failure. Proceedings of the National Academy of Sciences USA. 2022; 119(34): e2207503119. doi: 10.1073/pnas.2207503119.

350. Tian D, Li W, Heffron CL, Wang B, Mahsoub HM, Sooryanarain H, Hassebroek AM, Clark-Deener S, LeRoith T, X.J. Meng. 2022. Hepatitis E virus infects brain microvascular endothelial cells, crosses the blood-brain barrier, and invades the central nervous system. Proceedings of the National Academy of Sciences USA. 2022 Jun 14;119(24):e2201862119. doi: 10.1073/pnas.2201862119. 

349. Meng XJ. 2022. Hepatitis E virus.  In: Kaslow, R.A., Stanberry, L.R., Powers, A.M. (eds). Viral Infections of Humans: Epidemiology and Control, 6th edition Springer, New York, NY. https://doi.org/10.1007/978-1-4939-9544-8_18-1.

348. Meng XJ, Huang YW. 2021. Circoviridae and Anelloviridae. In: Fields Virology, 7th Edition (chapter 7). David M. Knipe and Peter M. Howley (eds). Lippincott Williams & Wilkins, Philadelphia, PA. pp197-211.

347. Sooryanarain H, Ahmed SA, X.J. Meng. 2021. Progesterone-Mediated Enhancement of Hepatitis E Virus Replication in Human Liver Cells. mBio. 2021:e0143421. doi: 10.1128/mBio.01434-21.

346. Maeda D.L., Tian D., Yu H., Dar N., Rajasekaran V., Meng S., Mahsoub H., Sooryanarain H., Wang B., Heffron C.L., Hassebroek A., LeRoith T., X.J. Meng, and S.L. Zeichner. 2021. Killed whole genome-reduced bacteria surface-expressed coronavirus fusion peptide vaccines protect against disease in a porcine model. Proceedings of the National Academy of Sciences USA. 2021;118(18):e2025622118. doi: 10.1073/pnas.2025622118. 

345. Meng XJ, Liang TJ. 2021. SARS-CoV-2 infection in the gastrointestinal tract: fecal-oral route of transmission for COVID-19? Gastroenterology. 2021;160(5):1467-1469.  

344. Wang B, and Meng XJ. 2021. Structural and molecular biology of hepatitis E virus. Computational and Structural Biotechnology Journal. 2021;19:1907-1916.   

343. Wang B, and X.J. Meng. 2021. Hepatitis E virus: host tropism and zoonotic infection. Current Opinion in Microbiology. 2021;59:8-15. doi: 10.1016/j.mib.2020.07.004. 

342. Meng XJ. 2021. Hepeviridae.  In: Bamford, D.H. and Zuckerman, M. (eds.) Encyclopedia of Virology, 4th Edition, vol. 2, pp. 397–403. Oxford: Academic Press.

341. Meng XJ, and Thiel V. 2020. Emerging and re-emerging porcine viruses. Virus Research. 290:198198. doi: 10.1016/j.virusres.

340. Tian D, D.M. Yugo, S.P. Kenney, C.L. Heffron, T. Opriessnig, A.K. Karuppannan, J. Bayne, P.G. Halbur, and X.J. Meng. 2020. Dissecting the potential role of hepatitis E virus ORF1 non-structural gene in cross-species infection by using intergenotypic chimeric viruses. Journal of Medical Virology. 2020 Jun 26. doi: 10.1002/jmv.26226.

339. Tian D, S. Subramaniam; C.L. Heffron, H.M. Mahsoub, H. Sooryanarain B. Wang, Q.M. Cao, A.M. Hassebroek, T. LeRoith, D.L. Foss, J.G. Calvert, and X.J. Meng. 2020. Construction and efficacy evaluation of novel swine leukocyte antigen (SLA) class I and class II allele-specific poly-T cell epitope vaccines against porcine reproductive and respiratory syndrome virus. Journal of General Virology. 2020 Nov;101(11):1191-1201. doi: 10.1099/jgv.0.001492. 

338. Sooryanarain H, X.J. Meng. 2020. Swine hepatitis E virus: cross-species infection and food safety.  Virus Research. 2020 Jul 15;284:197985. doi: 10.1016/j.virusres.2020.197985.  

337. Smith DB, J. Izopet, F. Nicot, P. Simmonds, S. Jameel, X.J. Meng, H. Norder, H. Okamoto, W.H.M Van der Poel, G. Reuter, and M.A. Purdy. 2020. Updated: proposed reference sequences for subtypes of hepatitis E virus (species Orthohepevirus A). Journal of General Virology. J Gen Virol. 2020 Jul;101(7):692-698. doi: 10.1099/jgv.0.001435. 

336. Lu Y, S. Clark-Deener, F. Gillam, C.L. Heffron, D. Tian, H. Sooryanarain, T. LeRoith, J. Zoghby, M. Henshaw, S. Waldrop, J. Pittman, X.J. Meng, and C. Zhang. 2020. Virus-like particle vaccine with B-cell epitope from porcine epidemic diarrhea virus (PEDV) incorporated into hepatitis B virus core capsid provides partial clinical alleviation against PEDV in neonatal piglets  through lactogenic immunity. Vaccine. 38(33):5212-5218. 

335. Lu Y,  F. Gillam, Q.M. Cao, A. Rizzo, X.J. Meng, and C. Zhang. 2020. Hepatitis B core antigen-based vaccine incorporated with both B- cell and T-cell epitopes demonstrates cross-neutralization against heterologous porcine reproductive and respiratory syndrome virus. Journal of Virological Methods. 2020 Nov;285:113945. doi: 10.1016/j.jviromet.2020.113945. 

334. Opriessnig T, A.K. Karuppanan, P.G. Halbur, J.G. Calvert, G.P Nitzel, S. Matzinger, and X.J. Meng. 2020. Porcine circovirus type 2a or 2b based experimental vaccines provide protection against PCV2d/porcine parvovirus 2 co-challenge. Vaccine. 38(8):1975-1981. 

333. Meng XJ, and HL Shivaprasad. 2020. Hepatitis E virus infection. In: Swayne DE, Boulianne M, Logue CM, McDougald LR, Nair V, and Suarez BL(eds). Diseases of Poultry, 14th Edition. Wiley Blackwell. Vol II: pp. 528-534 

332. Sooryanarain H, C.L. Heffron, and X.J. Meng. 2020. The U-rich untranslated regions (UTR) of the hepatitis E virus induces differential type I and type III interferon responses in a host cell-dependent manner. mBio. 2020;11(1):e03103-19. doi: 10.1128/mBio.03103-19.

331. Catanzaro N, and X.J. Meng. 2020. Induction of the unfolded protein response (UPR) suppresses porcine reproductive and respiratory syndrome virus (PRRSV) replication. Virus Research.  2020;276:197820. doi: 10.1016/j.virusres.2019.197820. 

330. Meng XJ. 2020. Hepatitis E virus: An emerging zoonotic virus causing acute and chronic liver disease.  In: I.M. Arias, H.J. Alter, J.L. Boyer, D.E. Cohen, D.A. Shafritz, S.S. Thorgeirsson, and A.W. Wolkoff,  (eds): The Liver: Biology and Pathobiology, 6th edition. John Wiley & Sons Ltd, pp 915-925.

329. Sooryanarain H, C.L. Heffron, D.E. Hill, J. Fredericks, B.M. Rosenthal, S.R. Werre, T. Opriessnig, and X.J. Meng. 2020. Hepatitis E virus in pigs from slaughterhouses, United States, 2017-2019.  Emerging Infectious Diseases. 26(2);354-357. DOI: 10.3201/eid2602.191348.

328. Cao QM, D. Tian, C.L. Heffron, S. Subramaniam, T. Opriessnig, D.L. Foss, J.G. Calvert, and X.J. Meng. 2019. Cytotoxic T lymphocyte epitopes identified from a contemporary strain of porcine reproductive and respiratory syndrome virus enhance CD4+CD8+ T, CD8+ T, and gd T cell responses. Virology. 538:35-44.

327. Rogers E., M. Todd, F.W. Pierson, S.P. Kenney, C.L. Heffron, D.M. Yugo, S.R. Matzinger, E. Mircoff, M. Jones, P. Siegel, K. Hall, R.J. Etches, X.J. Meng, and T. LeRoith.  2019. CD8+ T lymphocytes but not B lymphocytes are required for protection against chronic hepatitis E virus infection in chickens. Journal of Medical Virology. 91(11):1960-1969. 

326. Opriessnig T, A. Castro, A.K. Karuppanan, P.C. Gauger, P.G. Halbur, S.R. Matzinger, and XJ Meng. 2019. A porcine circovirus 2 (PCV2) b-based experimental vaccine is effective in the PCV2b-Mycoplasma hyopneumoniae coinfection pig model. Vaccine. 37(44):6688-6695. 

325. Meng XJ, Halbur PG, and Opriessnig. 2019. Hepatitis E virus. In: Jianqiang Zhang, Jeffrey J. Zimmerman, (eds): Diseases of Swine, 11th Edition. John Wiley & Sons Ltd. pp 544-549. 

324. Kenney SP and Meng XJ. 2019. Hepatitis E virus: animal models and zoonosis. Annual Review of Animal Biosciences.  7:427-448. 

323. Sooryanarain H, and X.J. Meng. 2019. Hepatitis E virus: Reasons for emergence in humans. Current Opinion in Virology. 34:10-17. 

322. Catanzaro N, and X.J. Meng. 2019. Porcine reproductive and respiratory syndrome virus (PRRSV)-induced stress granules are associated with viral replication complexes and suppression of host translation. Virus Research. 265:47-56. 

321. Yugo DM, C.M. Cossaboom, C.L. Heffron, Y.W. Huang, S.P. Kenney, A.R. Woolums, D.J. Hurley, T. Opriessnig, L. Li, E. Delwart, I. Kanevsky, and X.J. Meng. 2019. Evidence for an Unknown Agent Antigenically Related to the Hepatitis E Virus in Dairy Cows in the United States. Journal of Medical Virology. 91(4): 677-686. 

320. Yugo DM, C.L. Heffron, J. Ryu, K. Uh, S. Subramaniam, S.M. Matzinger, C. Overend, D.J. Cao, S.P. Kenney, H. Sooryanarain, T. Cecere, T. LeRoith, L. Yuan, N. Jue, S. Clark-Deener, K. Lee, and X.J. Meng. 2018. Infection dynamics of hepatitis E virus in wild-type and immunoglobulin heavy chain knockout JH (-/-) gnotobiotic piglets.  Journal of Virology. 2018 Oct 12;92(21). pii: e01208-18 

319. Cao D, H. Sooryanarain, D.M. Yugo, D. Tian, A.J. Rogers, C.L. Heffron, A.T. Narayanappa, T. LeRoith, C. Overend, S.R. Matzinger, S. Elankumaran, J.R. Hermann, A.R. Patterson, and X.J. Meng. 2018. Evaluation of the pathogenicity of mammalian orthoreovirus type 3 (MRV3) in gnotobiotic pigs and of the efficacy of an inactivated vaccine against MRV3 infection in neonatal conventional piglets. Veterinary Microbiology.  224:23-30. 

318. Cao QM, Ni YY, Cao D, Tian D, Yugo DM, Heffron CL, Overend C, Subramaniam S, Rogers AJ, Catanzaro N, LeRoith T, Roberts PC, Meng XJ. 2018. Recombinant porcine reproductive and respiratory syndrome virus expressing membrane-bound IL-15 as immunomodulatory adjuvant enhances NK and γδ T cell responses and confers heterologous protection. Journal of Virology. pii: JVI.00007-18. doi: 10.1128/JVI.00007-18. 

317. Cao D, Y.Y. Ni, M. Walker, Y.W. Huang, and X.J. Meng. 2018. Roles of the genomic sequence surrounding the stem-loop structure in the junction region including the 3’ terminus of ORF1 in hepatitis E virus replication. Journal of Medical Virology.  90(9):1524-1531. 

316. Kenney SP, and X.J. Meng. 2019. Hepatitis E virus genome structure and replication strategy. In: Christopher Walker, and Stanley Lemon (eds). Enteric Hepatitis Viruses. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York. pp.97-113. Cold Spring Harb Perspect Med. doi: 10.1101/cshperspect.a031724. 

315. Subramaniam S, C. Overend, D.M. Yugo, C.L. Heffron, S.R. Matzinger, A.J. Rogers, D. Tian, Q.M. Cao, S.P. Kenney, and X.J. Meng. 2018. Isolation of peripheral blood CD8 T cells specific to porcine reproductive and respiratory syndrome virus utilizing porcine CD137 activation marker. Viral Immunology. 31(4):333-337. 

314. Cao D, Ni YY, and X.J. Meng. 2018. Substitution of amino acid residue V1213 in the helicase gene of the genotype 3 hepatitis E virus reduces virus replication. Virology Journal. 15(1):32. https://doi.org/10.1186/s12985-018-0943-5. 

313. Van der Poel WHM, Harry Dalton, Reimar Johne, Nicole Pavio, Martijn Bouwknegt, Ting Wu, Nigel Cook, and X.J. Meng. 2018. Knowledge gaps and research priorities in the prevention and control of hepatitis E virus infection. Transboundary and Emerging Diseases. 65 Suppl 1:22-29. doi: 10.1111/tbed.12760. 

312. Subramaniam S, Yugo DM, Heffron CL, Rogers AJ, Sooryanarain H, LeRoith T, Overend C, Cao D, Meng XJ. 2018. Vaccination of sows with a dendritic cell-targeted porcine epidemic diarrhea virus S1 protein-based candidate vaccine reduced viral shedding but exacerbated gross pathological lesions in suckling neonatal piglets. Journal of General Virology. 99(2):230-239.  

311. Tian D, Sooryanarain H, Matzinger SR, Gauger PC, Karuppannan AK, Elankumaran S, Opriessnig T, Meng XJ. 2017. Protective efficacy of a virus-vectored multi-component vaccine against porcine reproductive and respiratory syndrome virus, porcine circovirus type 2 and swine influenza virus. Journal of General Virology. 98(12):3026-3036. 

310. Purdy MA, Harrison TA, Jameel S, Meng XJ, Okamoto S, Van der Poel WHM, and Smith DB. 2017. Hepeviridae. In: Virus Taxonomy, 10th Report of the ICTV [https://talk.ictvonline.org/ictv-reports/ictv_online_report/]. 

309. Opriessnig T, Gerber P, Matzinger SR, Meng XJ, and Halbur PG. 2017. Markedly different immune responses and virus kinetics in littermates infected with porcine circovirus type 2 or porcine parvovirus type 1.  Veterinary Immunology and Immunopathology. 191:51-59. 

308. Purdy MA, T.J. Harrison, S. Jameel, X.J. Meng, H. Okamoto, W.H.M. Van der Poel, D.B. Smith. 2017.  ICTV Virus Taxonomy Profile: Hepeviridae. Journal of General Virology. 98(11):2645-2646. 

307. Rogers AJ, Huang YW, Heffron CL, Opriessnig T, Patterson AR, and X.J. Meng. 2017.  Prevalence of the novel Torque teno sus virus (TTSuV) species k2b from pigs in the United States and lack of association with postweaning multisystemic wasting syndrome or mulberry heart disease. Transboundary and Emerging Diseases. 64:1877-1883.

306. Subramaniam S, Piñeyro P, Derscheid RJ, Darin MM, Magstadt DR, and X.J. Meng. 2017. Dendritic cell-targeted porcine reproductive and respiratory syndrome virus (PRRSV) antigens adjuvanted with polyinosinic-polycytidylic acid (poly (I:C)) induced non-protective immune responses against heterologous type 2 PRRSV challenge in pigs.  Veterinary Immunology and Immunopathology. 190:18-25. 

305. Sooryanarain H, A.J. Rogers, D. Cao, M.E.R. Haac, Y.A. Karpe, and X.J. Meng. 2017. ISG15 modulates type-I interferon signaling and antiviral response during hepatitis E virus replication. Journal of Virology. 91(19). pii: e00621-17. doi: 10.1128/JVI.00621-17. 

304. Cao D, Cao QM, Subramaniam S, Yugo DM, Heffron CL, Rogers AJ, Kenney SP, Tian D, Matzinger SR, Overend C, Catanzaro N, LeRoith T, Wang H, Piñeyro P, Lindstrom N, Clark-Deener S, Yuan L, and X.J. Meng.  2017. Pig model mimicking chronic hepatitis E virus infection in immunocompromised patients to assess immune correlates during chronicity. Proceedings of the National Academy of Sciences USA. 114(27):6914-6923. 

303. Tian D, Cao D, Heffron CL, Yugo DM, Rogers AJ, Overend C, Matzinger SR, Subramaniam S, Opriessnig T, LeRoith T, and X.J. Meng. 2017. Enhancing heterologous protection in pigs vaccinated with chimeric porcine reproductive and respiratory syndrome virus containing the full-length sequences of shuffled structural genes of multiple heterologous strains. Vaccine. 35(18):2427-2434.

302. Evenson D, P.F. Gerber, C.T. Xiao, P.G. Halbur, C. Wang, D. Tian, Y.Y. Ni, X.J. Meng, and T. Opriessnig. 2016. A porcine reproductive and respiratory syndrome virus candidate vaccine based on the synthetic attenuated virus engineering approach is attenuated and effective in protecting against homologous virus challenge. Vaccine. 34(46):5546-5553.  

301. Subramaniam S, Cao D, Tian D, Cao QM, Overend C, Yugo DM, Matzinger SR, Rogers AJ, Heffron CL, Catanzaro N, Kenney SP, Opriessnig T, Huang YW, Labarque G, Wu SQ, Meng XJ. 2017. Efficient priming of CD4 T cells by Langerin-expressing dendritic cells targeted with porcine epidemic diarrhea virus spike protein domains in pigs. Virus Research. 227:212-219. 

300. Sadeghi R, Kapusinszky B, Yugo DM, Phan TG, Deng X, Kanevsky I, Opriessnig T, Woolums AR, Hurley DJ, X.J. Meng, and Delwart E. 2017. Virome of US bovine calf serum. Biologicals. 46:64-67. 

299. Opriessnig T, Xiao CT, Halbur PG, Matzinger SR, and X.J. Meng. 2017. A commercial porcine circovirus (PCV) type 2a-based vaccine reduces PCV2d viremia and shedding and prevents PCV2d transmission to naïve pigs under experimental conditions. Vaccine. 35(2):248-254. 

298. Gerber PF, Xiao CT, Lager L, Crawford K, Kulshreshtha V, Cao D, X.J. Meng, T. Opriessnig. 2017. Increased frequency of porcine epidemic diarrhea virus shedding and lesions in suckling pigs compared to nursery pigs and protective immunity in nursery pigs after homologous re-challenge. Veterinary Research. 47(1):118. 

297. Afghah Z, Webb B, Meng X.J., and Ramamoorthy S. 2016. Ten years of PCV2 vaccines and vaccination: Is eradication a possibility?  Veterinary Microbiology. 2016 Oct 13. pii: S0378-1135(16)30452-7. 

296. Meng XJ. 2016. Expanding host range and cross-species infection of hepatitis E virus. Plos Pathogens. 12(8): e1005695. doi:10.1371/journal.ppat.1005695. 

295. Meng X.J. 2016.  Circoviridae and Anelloviridae.  In: MacLachlan JN, and Dubovi EJ (eds) Fenners Veterinary Virology, 5th ed Chapter 13.  Elsevier Academic Press. pp259-268.

294. Inzana, T.J., X.J. Meng, T. Opriessnig, and L. Ballweber. 2016.  Commercial Methods in Clinical Veterinary Microbiology. In: Mannual of Commercial Methods in Clinical Microbiology, 2nd edition.  American Society for Microbiology Press, Washington, DC.  Chapter 19. pp 328-356.

293. Meng X.J. 2016. Other Viruses: Member of the Family Hepeviridae. In: MacLachlan JN, and Dubovi EJ (eds) Fenners Veterinary Virology, 5th ed.  Chapter 30.  Elsevier Academic Press. Pp 547-551. 

292. Matzinger SR, Opriessnig T, Xiao CT, Cantazaro N, Beach NM, Slade DE, Nitzel GP, and X.J. Meng. 2016. A chimeric virus created by DNA shuffling of the capsid genes of different subtypes of porcine circovirus type 2 (PCV2) in the backbone of the non-pathogenic PCV1 induces protective immunity against the predominant PCV2b and the emerging PCV2d in pigs. Virology. 498:82-93. 

291. Yugo DM, Hauck R, Shivaprasad HL, and X.J. Meng.  2016. Hepatitis Virus Infections in Poultry. Avian Diseases. 60:576-588. 

290. Piñeyro PE, Subramaniam S, Kenney SP, Heffron CL, Giménez-Lirola LG, and X.J. Meng. 2016.  Modulation of pro-inflammatory cytokines in monocyte-derived dendritic cells (MoDCs) by porcine reproductive and respiratory syndrome virus (PRRSV) through interaction with the porcine intercellular-adeshion-molecule-3-grabbing non-integrin (pDC-SIGN). Viral Immunology.  29(10):546-556. 

289. Xia M, Wei C, Wang L, Cao D, X.J. Meng, Jiang X, and Tan M. 2016. A trivalent vaccine candidate against hepatitis E virus, norovirus, and astrovirus. Vaccine. 34(7):905-913. 

288. Xia M, Wei C, Wang L, Cao D, X.J. Meng, Jiang X, and Tan M. 2016. Development and evaluation of two subunit vaccine candidates containing antigens of hepatitis E virus, rotavirus and astrovirus.  Scientific Reports. 6:25735. doi: 10.1038/srep25735. 

287. Cossaboom CM, Heffron CL, Cao D, Yugo DM, Houk-Miles AE, Lindsay DS, Zajac AM, Bertke AS, Elvinger F, and X.J. Meng. 2016. Risk Factors and Sources of Foodborne Hepatitis E Virus Infection in the United States. Journal of Medical Virology. 88(9):1641-5.

286. Smith DB, Simmonds P, Izopet J, Jameel S, Harrison TJ, X.J. Meng, Okamoto H, W.H.M. Van der Poel, and M.A. Purdy. 2016. Proposed reference sequences for Hepatitis E virus subtypes. Journal of General Virology. 97(3):537-42. 

285. Carnaccini S, Shivaprasad HL, Cutler G, Bland M, X.J. Meng, Kenney SP, Bickford AA, Cooper G, Charlton B, Sentíes-Cué CG. 2016. Characterization of Seven Outbreaks of Hemorrhagic Hepatopathy Syndrome in Commercial Pullets Following the Administration of a Salmonella Enteritidis Bacterin in California. Avian Diseases. 60(1):33-42. 

284. Cao QM, Subramaniam S, Ni YY, Cao D, and X.J. Meng. 2016. The non-structural protein Nsp2TF of porcine reproductive and respiratory syndrome virus down-regulates the expression of Swine Leukocyte Antigen class I.  Virology 491:115-124. 

283. Tian D, and X.J. Meng. 2016. Amino acid residues Ala283 and His421 in the RNA-dependent RNA polymerase of porcine reproductive and respiratory syndrome virus play important roles in viral Ribavirin sensitivity and quasispecies diversity. Journal of General Virology. 97:53-59. 

282. Piñeyro PE, Kenney SP, Gimenez-Lirola LG, Opriessnig T, Tian D, Heffron CL, and X.J. Meng. 2016. Evaluation of the use of non-pathogenic porcine circovirus type 1 as a vaccine delivery virus vector to express antigenic epitopes of porcine reproductive and respiratory syndrome virus. Virus Research. 213:100-108. 

281. Gerber PF, D.W. Trampel, E.M. Willinghan, P. Billam, X.J. Meng, and T. Opriessnig. 2015. Subclinical avian hepatitis E virus infection in layer flocks in the United States. The Veterinary Journal.  206(3): 304-311. 

280. Richmond O, T.E. Cecere, E. Edrogan, X.J. Meng, P. Piñeyro, S. Subramaniam, S.M. Todd, and T. LeRoith. 2015. PD-L1 expression is increased in monocyte derived dendritic cells in response to porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus infections. Veterinary Immunology and Immunopathology. 168(1-2):24-29. 

279. Kenney SP, Wentworth JL, Heffron CL, Meng XJ. 2015. Replacement of the hepatitis E virus ORF3 protein PxxP motif with heterologous late domain motifs affects virusrelease via interaction with TSG101. Virology. 486:198-208. 

278. Richmond O, T.E. Cecere, E. Erdogan, X.J. Meng, P. Pineyro, S. Subramaniam, S.M Todd, T. LeRoith. 2015. The PD-L1/CD86 ratio is increased in dendritic cells co-infected with porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus, and the PD-L1/PD-1 axis is associated with anergy, apoptosis, and the induction of regulatory T-cells in porcine lymphocytes. Veterinary Microbiology. 180(3-4):223-9. 

277. Tian D, Ni YY, Zhou L, Opriessnig T, Cao D, Piñeyro P, Yugo DM, Cao Q, Overend C, Heffron CL, Halbur PG, Pearce DS, Calvert JG, and Meng XJ. 2015. Chimeric porcine reproductive and respiratory syndrome virus containing shuffled multiple envelope genes confers cross-protection in pigs. Virology. 485:402-413. 

276. Piñeyro PE, Kenney SP, Giménez-Lirola LG, Heffron CL, Matzinger SR, Opriessnig T, and X.J. Meng. 2015. Expression of antigenic epitopes of porcine reproductive and respiratory syndrome virus (PRRSV) in a modified live-attenuated porcine circovirus type 2 (PCV2) vaccine virus (PCV1-2a) as a potential bivalent vaccine against both PCV2 and PRRSV. Virus Research. 210:154-164. 

275.  Kenney SP and Meng XJ. 2015. Therapeutic targets for the treatment of hepatitis E virus infection.  Expert Opinion on Therapeutic Targets. 19(9):1245-1260. 

274. Murthy AM, Y.Y. Ni, X.J. Meng, and C. Zhang. 2015. Production and evaluation of virus-like particles displaying immunogenic epitopes of porcine reproductive and respiratory syndrome virus (PRRSV). International Journal of Molecular Sciences. 16(4):8382-96.

273. Renukaradhya GJ, Meng XJ, Clavert JG, Roof M, and Lager KM. Inactivated and subunit vaccines against porcine reproductive and respiratory syndrome: Current status and future direction. Vaccine. 33(27):3065-3072.

272. Nan Y, Ma Z, Kannan H, Stein DA, Iversen PI, X.J. Meng, and Zhang YJ. 2015. Inhibition of hepatitis E virus replication by peptide-conjugated phosphorodiamidate morpholino oligomers.  Antiviral Research 20:134-9. 

271. Renukaradhya GJ, Meng XJ, Clavert JG, Roof M, and Lager KM. 2015. Live porcine reproductive and respiratory syndrome virus vaccines: Current status and future direction. Vaccine. 33(33):4069-80. 

270. Kenney SP, and X.J. Meng. 2015. The SH3 Binding Domain within the Nucleocapsid Protein of Porcine Reproductive and Respiratory Syndrome Virus Interacts with Cellular Proteins STAMI, TXK, Fyn, Hck, and Cortactin. Virus Research 204:31-39. 

269. Thimmasandra Narayanappa A, Sooryanarain H, Deventhiran J, Cao D, Ammayappan Venkatachalam B, Kambiranda D, LeRoith T, Heffron CL, Lindstrom N, Hall K, Jobst P, Sexton C, Meng XJ, Elankumaran S. 2015. A novel pathogenic mammalian orthoreovirus from diarrheic pigs and swine blood meal in the United States. mBio 6(3):e00593-15. doi:10.1128/mBio.00593-15.

268. Kenney SP, and X.J. Meng. 2015. Identification and fine mapping of nuclear and nucleolar localization signals within the human ribosomal protein S17. Plos One. 10(4):e0124396 

267. Kenney SP, and X.J. Meng. 2015. The Lysine Residues within the Human Ribosomal Protein S17 (RPS17) Sequence Naturally Inserted into the Viral Nonstructural Protein of a Unique Strain of Hepatitis E Virus are Important for Enhanced Virus Replication. Journal of Virology.  89:3793-3803.

266. Park SJ, Lee B-W, Moon H-W, Sung HW, Yoon B-I, Meng XJ, and Kwon HM. 2015. Construction of an infectious cDNA clone of genotype 1 avian hepatitis E virus: Characterization of its pathogenicity in broiler breeders and demonstration of its utility in studying the role of the hypervariable region in virus replication. Journal of General Virology. 96(Pt 5):1015-26. 

265. Pavio N, X.J. Meng, and V. Doceul. 2015.  Zoonotic origin of hepatitis E.  Current Opinion in Virology.  10:34-41. 

264. Subramaniam S., P. Pineyro, D. Tian, C. Overend, D.M. Yugo, S.R. Matzinger, A.J. Rogers, M.E.R. Haac, Q. Cao, C.L. Heffron, N. Catanzaro, S.P. Kenney, Y.W. Huang, T. Opriessnig, and X.J. Meng. 2014.  In vivo targeting of porcine reproductive and respiratory syndrome virus antigen through porcine DC-SIGN to dendritic cells elicits antigen-specific CD4 T cell immunity in pigs. Vaccine. 32:6768-6775.

263. Meng X.J. 2014. Hepatitis E. In: Kaslow RA, Stanberry LA, and LeDuc JW (eds). Viral Infections of Humans: Epidemiology and Control, 5th Edition. Springer Publishing, NY. pp 439-454.

262. Opriessnig T, Xiao CT, Gerber PF, Halbur PG, Matzinger SR, and X.J. Meng. 2014. Mutant USA strain of porcine circovirus type 2 (mPCV2) exhibits similar virulence to the classical PCV2a and PCV2b strains in caesarian-derived colostrum-deprived pigs. Journal of General Virology. 95(Pt 11):2495-503.

261. Smith DB, P. Simmonds, S. Jameel, T.J. Harrison, X.J. Meng, H. Okamoto, W.H.M. Van der Poel, and M.A. Purdy. 2014. Consensus proposals for classification of the family Hepeviridae.  Journal of General Virology. 95(Pt 10):2223-32.

260. Opriessnig T, P.F. Gerber, C.T. Xiao, P.G. Halbur, S.R. Matzinger, and X.J. Meng. 2014. Commercial PCV2a-based vaccines are effective in protecting naturally PCV2b-infected finisher pigs against experimental challenge with a 2012 mutant PCV2. Vaccine. 32(34):4342-4348.

259. Wang L, Xia M, Huang P, Fang H, Cao D, Meng X.J., McNeal M, Jiang X, and Tan M. 2014. Branched-linear and agglomerate protein polymers as vaccine and vaccine platform.  Biomaterials 35: 8427-8438. 

258. Yugo DM, C.M. Cossaboom, and X.J. Meng. 2014. Naturally occurring animal models of human hepatitis E virus infection. ILAR Journal. 55(1): 187-199.

257. Giménez-Lirola LG, P.F. Gerber, R.R. Rowland, P.G. Halbur, Y.W. Huang, X.J. Meng, and T. Opriessnig. 2014. Development and validation of a 4-plex antibody assay for simultaneous detection of IgG antibodies against Torque teno sus virus 1 (TTSuV1), TTSuV2, and porcine reproductive and respiratory syndrome virus types 1 and 2. Research in Veterinary Sciences 96(3):543-550. 

256. Gerber PF, Xiao CT, Cao D, X.J. Meng, and T. Opriessnig. 2014. Comparison of real-time reverse transcriptase (RT)-PCR assays for detection of swine hepatitis E virus in fecal samples. Journal of Clinical Microbiology 52:1045-1051. 

255. Gerber PF, L.G. Giménez-Lirola, P.G. Halbur, L. Zhou, X.J. Meng, Y. Fang, and T. Opriessnig. 2014. Comparison of commercial enzyme-linked immunosorbent assays and fluorescent microbead immunoassays for detection of antibodies against porcine reproductive and respiratory syndrome virus in boars. Journal of Virological Methods. 197:63-66. 

254. Hemann M, N.M. Beach, X.J. Meng, P.G. Halbur, and T. Opriessnig. 2014. A live-attenuated and an inactivated chimeric porcine circovirus (PCV) vaccine are both effective at inducing a humoral immune response and reducing PCV2 viremia and intrauterine infection in female swine of breeding age. Canadian Journal of Veterinary Research. 78(1):8-16.

253. Ni YY, Z. Zhao, T. Opriessnig, S. Subramaniam, L. Zhou, D. Cao, Q. Cao, H. Yang, and X.J. Meng. 2014. Computer-aided codon-pairs deoptimization of the major envelope GP5 gene attenuates porcine reproductive and respiratory syndrome virus. Virology. 450-451:132-139. 

252. Wang L, D. Cao, C. Wei, X.J. Meng, X.J., and M. Tan. 2014. A dual vaccine candidate against norovirus and hepatitis E virus. Vaccine. 32:445-452. 

251. Huang YW, A.W. Dickerman, P. Pineyro, L. Li, L. Fang, R. Kiehne, T. Opriessnig, and X.J. Meng. 2013. Origin, evolution, and genotyping of emergent porcine endemic diarrhea virus (PEDV) strains in the United States.  mBio. 4(5):e00737-13. doi:10.1128/mBio.00737-13.

250. Yugo DM and X.J. Meng.  2013. Hepatitis E Virus: Foodborne, Waterborne and Zoonotic Transmission. International Journal of Environmental Research and Public Health. 10:4507-4533. 

249. Yin SH, Gerbera PF, Xiao CT, Beach NM, X.J. Meng, Halbur PG, and T. Opriessnig. 2013. Concurrent porcine circovirus type 2a (PCV2a) or PCV2b infection increases the rates of amino acid mutations of porcine reproductive and respiratory syndrome virus (PRRSV) during serial passages in pigs. Virus Research. 178(2):445-51. 

248. Owolodun OA, Giménez-Lirola LG, Gerber P, Sanford BJ, Feagins AR, X.J. Meng, Halbur PG, and T. Opriessnig. 2013. Development of a fluorescent microbead-based immunoassay for the detection of hepatitis E virus IgM and IgG antibodies in pigs and comparison to an enzyme-linked immunoassay. Journal of Virological Methods. 193:278-283. 

247. Zhou L, Y.Y. Ni, P. Piñeyro, C.M. Cossaboom, S. Subramaniam, B.J. Sanford, B.A. Dryman, Y.W. Huang, and X.J. Meng. 2013. Broadening the heterologous cross-neutralizing antibody inducing ability of porcine reproductive and respiratory syndrome virus by breeding the GP4 or M genes. PLoS ONE. 8(6):e66645. doi:10.1371/journal.pone.0066645.

246. Meng XJ, and HL Shivaprasad. 2013. Avian hepatitis E virus infections. In: Swayne DE et al (eds) Diseases of Poultry, 13th Edition. Blackwell Publishing Press. pp. 494-512. 

245.  Meng XJ. 2013. Hepatitis E Virus: Structural and Molecular Biology. In: Viral Hepatitis, 4th edition. Howard C. Thomas, Anna SF Lok, Stephen A. Locarnini, and Arie Zuckerman (eds). Wiley-Blackwell. pp 419-430. 

244. Ni YY, T. Opriessnig, L. Zhou, D. Cao, Y.W. Huang, P.G. Halbur, and X.J. Meng. 2013. Attenuation of porcine reproductive and respiratory syndrome virus by molecular breeding of the virus envelope genes from genetically divergent strains. Journal of Virology. 87:304-313.

243. Opriessnig T, K. O’Neill, P. Gerber, A. M. Gomes de Castro, L. G. Gimenéz-Lirola, N.M. Beach, L. Zhou, X.J. Meng, C. Wang, P.G. Halbur. 2013. A PCV2 vaccine based on genotype 2b is more effective than a 2a-based vaccine to protect against PCV2b or combined PCV2a/2b viremia in pigs with concurrent PCV2, PRRSV and PPV infection. Vaccine. 31:487-94.

242. Gerber PF, K. O’Neill, O. Owolodun, C. Wang, K. Harmon, J. Zhang, P.G. Halbur, L. Zhou, X.J. Meng, and T. Opriessnig. 2013. Comparison of commercial real-time RT-PCR kits for reliable, early and rapid detection of different heterologous strains of porcine reproductive and respiratory syndrome virus (PRRSV) in experimentally infected or negative boars using different sample types (semen, oral fluids, serum, blood swabs). Journal of Clinical Microbiology. 51(2):547-56. 

241. Meng XJ. 2013. Zoonotic and foodborne transmission of hepatitis E virus. Seminars in Liver Diseases. 33(1):41-49.  

240. Meng XJ. 2013. Circoviridae. In: Fields Virology, 6th Edition. David M. Knipe and Peter M. Howley (eds). Lippincott Williams & Wilkins, Philadelphia, PA. pp1792-1801. 

239. Meng XJ. 2013. Porcine circovirus: Pathogenesis and interaction with the immune system.  Annual Review of Animal Biosciences. 1:43-64. 

238. Sanford, B.J., S.U. Emerson, R.H. Purcell, R.E. Engle, B.A. Dryman, T.E. Cecere, V. Buechner-Maxwell, D.P. Sponenberg, and X.J. Meng. 2013. Serological evidence for a hepatitis E virus (HEV)-related agent in goats in the United States. Transboundary and Emerging Diseases. 60(6):538-545. 

237. Hu, J., Ni, Y., X.J. Meng, Zhang, C. 2012. Expression and purification of a chimeric protein consisting of the ectodomains of M and GP5 proteins of porcine reproductive and respiratory syndrome virus (PRRSV). Journal of Chromatography B. 911: 43-48. 

236. Cossaboom CM, L. Córdoba, D. Cao, Y.Y. Ni, and X.J. Meng. 2012. Complete genome sequence of hepatitis E virus from rabbits in the United States. Journal of Virology. 86:13124-13125.

235. Zhou L, Y.Y. Ni, P. Piñeyro, B.J. Sanford, C.M. Cossaboom, D.J. Cao, Y.W. Huang, and X.J. Meng. 2012. DNA shuffling of the GP3 genes of porcine reproductive and respiratory syndrome virus (PRRSV) produces a chimeric virus with an improved cross-neutralizing ability against a heterologous PRRSV strain. Virology. 434:96-109.

234. Córdoba L, A.R. Feagins, T. Opriessnig, C.M. Cossaboom, B.A. Dryman, Y.W. Huang, and X.J. Meng. 2012. Rescue of a genotype 4 human hepatitis E virus (HEV) from cloned cDNA and characterization of intergenotypic chimeric viruses in cultured human liver cells and in pigs. Journal of General Virology. 93(Pt 10):2183-2194.

233. Cecere TE, X.J. Meng, K. Pelzer, S.M. Todd, N.M. Beach, Y.Y. Ni, and T. LeRoith. 2012. Co-infection of porcine dendritic cells with porcine circovirus type 2a (PCV2a) and genotype II porcine reproductive and respiratory syndrome virus (PRRSV) induces CD4(+)CD25(+)FoxP3(+) T cells in vitro. Veterinary Microbiology. 160(1-2):233-239. 

232. Huang YW, K.K. Harrall, B.A. Dryman, T. Opriessnig, E.M. Vaughn, M.B. Roof, and X.J. Meng. 2012. Serological profile of Torque teno sus virus species 1 (TTSuV1) in pigs and antigenic relationships between two TTSuV1 genotypes (1a and 1b), between two species (TTSuV1 and 2), and between porcine and human anelloviruses. Journal of Virology. 86(19):10628-10639.

231. Kwon H.-M., H.-W. Sung, and X.J. Meng. 2012. Serological prevalence, genetic identification and characterization of the first strains of avian hepatitis E virus from chickens in Korea. Virus Genes. 45:237-245. 

230. Cao D, and X.J. Meng. 2012. Molecular biology and replication of hepatitis E virus.  Emerging Microbes & Infections. (2012) 1(8):e17; doi:10.1038/emi.2012.7. 

229. Sanford, B.J., T. Opriessnig, S.P. Kenney, B.A. Dryman, Córdoba L, and X.J. Meng. 2012. Assessment of the cross-protective capability of recombinant capsid proteins derived from pig, rat, and avian hepatitis E viruses (HEV) against challenge with a genotype 3 HEV in pigs. Vaccine. 30(44): 6249-6255.

228. Cossaboom CM, L. Córdoba, B.J. Sanford, P. Pineyro, B.A. Dryman, Y. Wang, and X.J. Meng. 2012. Cross-species infection of pigs with a novel rabbit, but not rat, strain of hepatitis E virus isolated in the United States. Journal of General Virology.  93:1687-1695.

227. Hemann H, H.G. Shen, N.M. Beach, X.J. Meng, P.G. Halbur, and T. Opriessnig. 2012. Expression of human CD46 has no effect on porcine circovirus type 2 infection and shedding in the experimental pig model. Veterinary Research Communications. 36:187-193. 

226. Xiao CT, L.G. Giménez-Lirola, Y.W. Huang, X.J. Meng, P.G. Halbur, T. Opriessnig. 2012. The prevalence of Torque teno sus virus (TTSuV) is common and increases with the age of growing pigs in the United States. Journal of Virological Methods. 183(1):40-4.

225. Sinha A, K. Lin, M. Hemann, H. Shen, N.M. Beach, C. Ledesma, X.J. Meng, C. Wang, P. G. Halbur, and T. Opriessnig. 2012. ORF1 but not ORF2 dependent differences are important for in vitro replication of PCV2 in porcine alveolar macrophages singularly or coinfected with PRRSV. Veterinary Microbiology. 158(1-2):95-103.

224. Opriessnig T, P.C. Gauger, K.S. Faaberg, H. Shen, N.M. Beach, X.J Meng, C. Wang, P.G. Halbur. 2012. Effect of porcine circovirus type 2a or 2b on infection kinetics and pathogenicity of two genetically divergent strains of porcine reproductive and respiratory syndrome virus in the conventional pig model. Veterinary Microbiology. 158(1-2):69-81.

223. Hemann M, N.M. Beach, X.J. Meng, P.G. Halbur, T. Opriessnig. 2012. Vaccination with inactivated or live-attenuated chimeric PCV1-2 results in decreased viremia in challenge-exposed pigs and may reduce transmission of PCV2. Veterinary Microbiology. 158(1-2):180-6. 

222. Huang YW, A.R. Patterson, T. Opriessnig, B.A. Dryman, A. Gallei, K.K. Harrall, E.M. Vaughn, M.B. Roof, and X.J. Meng. 2012. Rescue of a porcine anellovirus (Torque teno sus virus 2) from cloned genomic DNA in pigs. Journal of Virology.  86:6042-6054. 

221. Kenney S.P., R.S. Pudupakam, Y.W. Huang, F.W. Pierson, T. LeRoith, and X.J. Meng. 2012. The PSAP motif within the ORF3 protein of an avian strain of the hepatitis E virus is not critical for viral infectivity in vivo but plays a role in virus release. Journal of Virology. 86(10):5637-46. 

220. Karpe Y.A., and X.J. Meng. 2012. Hepatitis E virus replication requires an active ubiquitin-proteasome system. Journal of Virology. 86(10):5948-52. 

219. Meng XJ. 2012. Emerging and re-emerging swine viruses. Transboundary and Emerging Diseases. 59 (Suppl. 1):85-102.

218. Meng XJ. 2012. Editorial: Spread like a wildfire--the omnipresence of porcine circovirus type 2 (PCV2) and its association with diseases. Virus Research. 164:1-3.

217. Hu J, Y.Y. Ni, B.A. Dryman, X.J. Meng, and C. Zhang. 2012. Plant-made oral subunit vaccine against porcine reproductive and respiratory syndrome virus (PRRSV) is immunogenic in mice. Vaccine. 30:2068-2074.

216. Meng X.J., P.G. Halbur, T. Opriessnig. 2012. Hepatitis E virus infection in swine. In: Jeffrey J. Zimmerman, Locke A. Karriker, Alejandro Ramirez, Kent J. Schwartz, Gregory W. Stevenson (eds): Diseases of Swine, 10th Edition. John Wiley & Sons, Inc. pp 554-556.

215. Kumar D, Beach N.M., X.J. Meng, and Hegde N.R. 2012. Use of PCR-based assays for the detection of the adventitious agent porcine circovirus type 1 (PCV1) in vaccines, and for confirming the identity of cell substrates and viruses used in vaccine production.  Journal of Virological Methods. 179(1):201-211.

214. Beach NM, and Meng XJ. 2012. Porcine circovirus type 2 (PCV2): current vaccine efficacy and future vaccine development. Virus Research. 164:33-42. 

213. Meng X.J., D.A. Anderson, V.A. Arankalle, S.U. Emerson, T.J. Harrison, S. Jameel, and H. Okamoto. 2012.  Hepeviridae.  In: Virus Taxonomy, 9th Report of the ICTV. King AMQ, M.J. Adams, E.B. Carstens, and E.J. Lefkowitz (eds), Elsevier Academic Press, London. pp 1021-1028.

212. Opriessnig T, J. Gomes-Neto, M. Hemann, H. Shen, N.M. Beach, Y.W. Huang, P.G. Halbur, and X.J. Meng. 2011. An experimental live chimeric porcine circovirus 1-2a vaccine is efficacious at decreasing porcine circovirus 2b viremia when administered intramuscularly or orally in a porcine circovirus 2b and porcine reproductive and respiratory syndrome virus dual-challenge model. Microbiology and Immunology. 55(12):863-73 

211. Dong C, Meng, X.J. Dai, J.H. Liang, A. R. Feagins, X.J. Meng, N. M. Belfiore, C. Bradford, J. L. Corn, C. Cray, G. E. Glass, M.L. Gordon, R.A. Hesse, D.L. Montgomery, W. L. Nicholson, A.A. Pilny, S. Ramamoorthy, D.D. Shaver, M. A. Purdy, H.A. Fields, S. Kamili, and C.G. Teo. 2011. Restricted enzooticity of hepatitis E virus genotypes 1 to 4 in the United States. Journal of Clinical Microbiology. 49(12):4164-4172. 

210. O’Neill KC, H.G. Shen, K. Lin, M. Hemann, N.M. Beach, X.J. Meng, P.G. Halbur, and T. Opriessnig. 2011. Studies on PCV2 vaccination of 5-day-old piglets. Clinical and Vaccine Immunology. 18:1865-1871.

209. Beach NM, L. Córdoba, S.P. Kenney, and X.J. Meng. 2011. Productive infection of human hepatocellular carcinoma cells by porcine circovirus type 1. Vaccine. 29:7303-7306. 

208. Cossaboom CM, L. Córdoba, B.A. Dryman, and X.J. Meng. 2011. Hepatitis E Virus in Rabbits, Virginia USA. Emerging Infectious Diseases. 17(11):2047-2049. 

207. Pudupakam, R.S., S. P. Kenney, L. Córdoba, Y. W. Huang, B. A. Dryman, T. LeRoith, F.W. Pierson, and X.J. Meng. 2011. Mutational analysis of the hypervariable region of the hepatitis E virus reveals its involvement in the efficiency of viral RNA replication. Journal of Virology. 85:10031–10040. 

206. Ni, Y.Y., Y.W. Huang, D.J. Cao, T. Opriessnig, and X.J. Meng. 2011. Establishment of a DNA-launched infectious clone for a highly pneumovirulent strain of type 2 porcine reproductive and respiratory syndrome virus: Identification and in vitro and in vivo characterization of a large spontaneous deletion in the nsp2 region. Virus Research. 160;264-273.

205. Meng X.J. 2011. From barnyard to food table: The omnipresence of hepatitis E virus and risk for zoonotic infection and food safety.  Virus Research. 161:23-30.

204. Krawczynski, K., X.J. Meng, and J. Rybczynska. 2011. Pathogenetic elements of hepatitis E and animal models of HEV infection. Virus Research. 161(1):78-83.

203. Sinha, H.G. Shen, S. Schalk, N.M. Beach, Y.W. Huang, X. J. Meng, P.G. Halbur, and T. Opriessnig. 2011. Porcine reproductive and respiratory syndrome virus (PRRSV) influences infection dynamics of porcine circovirus type 2 (PCV2) subtypes PCV2a and PCV2b by prolonging PCV2 viremia and shedding. Veterinary Microbiology. 152(3-4):235-46.

202. Opriessnig T, H. Shen, N. Pal, S. Rmamoorthy, Y.W. Huang, K.M. Lager, N.M. Beach, P.G. Halbur, and X.J. Meng. 2011. A live-attenuated chimeric PCV2 vaccine is transmitted to contact pigs but is not upregulated by concurrent infection with PPV and PRRSV and is efficacious in a PCV2a-PRRSV-PPV challenge model. Clinical and Vaccine Immunology. 18(8):1261-8. 

201. Baylis SA, Hanschmann KM, Blümel J, Nübling CM, and HEV Collaborative Study Group (Bouwknegt M, Rutjes S, Gärtner T, Kamili S, Drobeniuc J, Ijaz S, Izopet J, Kar P, Laue T, Matsubayashi K, Meldal B, Candotti D, Meng XJ, Mohn U, Nitsche A, Kaiser M, Pisani G, Marino F, Shih JW, Xiang GS, Thomas I, Uchida S, Wang Y, Geng Y, Wenzel J, Jilg W, Yu MY, Ma L). 2011. Standardization of hepatitis E virus (HEV) nucleic acid amplification technique-based assays: an initial study to evaluate a panel of HEV strains and investigate laboratory performance. Journal of Clinical Microbiology. 49(4):1234-1239.

200. Zhang H, U. Mohn, J.R. Prickett, S. Schalk, M. Motz, P.G. Halbur, A.R. Feagins, X.J. Meng, T. Opriessnig. 2011. Differences in capabilities of different enzyme immunoassays to detect anti-hepatitis E virus immunoglobulin G in pigs infected experimentally with hepatitis E virus genotype 3 or 4 and in pigs with unknown exposure. Journal of Virological Methods. 175(2):156-162.

199. Opriessnig T, D. Patel, R. Wang, P. G. Halbur, X.J. Meng, D. A. Stein, Y.J. Zhang. 2011. Inhibition of porcine reproductive and respiratory syndrome virus infection in piglets by a peptide-conjugated morpholino oligomer. Antiviral Research. 91:36-42.

198. Opriessnig T, D.M. Madson, S. Schalk, S. Brockmeier, H.G. Shen, N.M. Beach, X.J. Meng, R.B. Baker, E.L. Zanella, and P.G. Halbur. 2011. Porcine circovirus type 2 (PCV2) vaccination is effective in reducing disease and PCV2 shedding in semen of boars concurrently infected with PCV2 and Mycoplasma hyopneumoniae. Theriogenology. 76(2):351-360.

197. Sanford, B.J., Dryman BA, Huang YW, Feagins AR, LeRoith T, and X.J. Meng. 2011. Prior infection of pigs with a genotype 3 swine hepatitis E virus (HEV) protects against subsequent challenges with homologous and heterologous genotypes 3 and 4 human HEV. Virus Research. 159:17-22.

196. Huang YW, Harrall KK, Dryman BA, Beach NM, Kenney SP, Opriessnig T, Vaughn EM, Roof MB, and X.J. Meng. 2011. Expression of the putative ORF1 capsid protein of Torque teno sus virus 2 (TTSuV2) and development of Western blot and ELISA serodiagnostic assays: correlation between TTSuV2 viral load and IgG antibody level in pigs. Virus Research. 158:79-88.

195. Opriessnig T., D.M. Madson, M. Roof, S.M. Layton, S. Ramamoorthy, X.J Meng, P.G. Halbur. 2011. Experimental reproduction of porcine circovirus type 2 (PCV2)-associated enteritis in pigs infected with PCV2 alone or concurrently with Lawsonia intracellularis or Salmonella typhimuriumJournal of Comparative Pathology. 145(2-3):261-70.

194. Cordoba L, Y.W. Huang, T. Opriessnig, K.K. Harrall, N.M. Beach, C. Finkielstein, S.U. Emerson, and X.J. Meng. 2011. Three amino acid mutations (F51L, T59A and S390L) in the capsid protein of the hepatitis E virus collectively contribute to virus attenuation. Journal of Virology. 85(11):5338-5349. 

193. Beach NM, S.M. Smith, S. Ramamoorthy, and X.J. Meng. 2011. Chimeric porcine circoviruses (PCV) containing amino acid epitope tags in the C-terminus of the capsid gene are infectious and elicit both anti-epitope tag antibodies and anti-PCV2 neutralizing antibodies in pigs. Journal of Virology. 85:4591-4595. 

192. Meng XJ. 2011. Hepatitis E virus. In: Oxford Textbook of Zoonoses, Second Edition. Biology, Clinical Practice, and Public Health Control. S.R. Palmer, Lord Soulsby, P.R. Torgerson, and David W.G. Brown (eds). Oxford University Press, Oxford, UK. pp 475-483. 

191. Alberti KA, M.J. Estienne, X.J. Meng. 2011. Effect of vaccination of boars against porcine circovirus type 2 on ejaculate characteristics, serum antibody titers, viremia, and semen virus shedding. Journal of Animal Sciences. 89:1581-1587.

190. Feagins A.R., L. Cordoba, B.J. Sanford, B.A. Dryman, Y.W. Huang, S.U. Emerson, and X.J. Meng. 2011. Intergenotypic chimeric hepatitis E viruses (HEV) with the genotype 4 human HEV capsid gene in the backbone of genotype 3 swine HEV are infectious in pigs. Virus Research. 156; 141-146. 

189. Patterson A.R., Johnson J. K., Ramamoorthy S, Hesse R.A., Murtaugh M.P., Pogranichniy R.M., Erickson G.A., Carman S, Hause B, X.J. Meng, and Opriessnig T. 2011. Inter-laboratory comparison of PCV2 indirect immunofluorescent assay and ELISA results on experimentally infected animals. Journal of Veterinary Diagnostic Investigation. 23(2):206-12. 

188. Patterson AR, N.M. Juhan, D.M. Madson, X.J. Meng, P.G. Halbur and T. Opriessnig.  2011. Shedding and infection dynamics of porcine circovirus type 2 (PCV2) after experimental infection. Veterinary Microbiology. 149(1-2):91-8.  

187. Xia H, N. Wahlbergc, S. Beláka, X.J. Meng, and L. Liu. 2011. The emergence of genotypes 3 and 4 hepatitis E virus in swine and humans: a phylogenetic perspective. Archives of Virology.  156:121-124. 

186. Ramamoorthy S., T. Opriessnig, N. Pal, F.F. Huang, and X.J. Meng. 2011. Effect of an interferon-stimulated response element (ISRE) mutant of porcine circovirus type 2 (PCV2) on PCV2-induced pathological lesions in a porcine reproductive and respiratory syndrome virus (PRRSV) co-infection model. Veterinary Microbiology. 147:49–58.

185. Kwon H.M., T. LeRoith, R.S. Pudupakam, F.W. Pierson, Y.W. Huang, B.A. Dryman, and X.J. Meng. 2011. Construction of an infectious cDNA clone of avian hepatitis E virus (avian HEV) recovered from a clinically healthy chicken in the United States and characterization of its pathogenicity in specific-pathogen-free chickens. Veterinary Microbiology. 147:310-319. 

184. Opriessnig T, J.R. Prickett, D.M. Madson, H. Shen, N.M. Juhan, R.R. Pogranichniy, X.J. Meng, and P.G. Halbur. 2010. Porcine circovirus type 2 (PCV2)-infection and re-inoculation with homologous or heterologous strains: Virological, serological, pathological and clinical effects in growing pigs. Veterinary Research. 41(3):31.  

183. Sinha A, H.G. Shen, S. Schalk, N.M. Beach, Y.W. Huang, P.G. Halbur, X.J. Meng, T. Opriessnig. 2010. Porcine reproductive and respiratory syndrome virus (PRRSV) infection at the time of porcine circovirus type 2 (PCV2) vaccination has no impact on vaccine efficacy. Clinical and Vaccine Immunology. 17(12):1940-1945.  

182. Beach N.M., Ramamoorthy S, Opriessnig T, Wu S.Q, and X.J. Meng. 2010. Novel chimeric porcine circovirus (PCV) with the capsid gene of the emerging PCV2b subtype cloned in the genomic backbone of the non-pathogenic PCV1 is attenuated in vivo and induces protective and cross-protective immunity against PCV2b and PCV2a subtypes in pigs. Vaccine. 29:221-232. 

181. Shen HG, N. Beach, Y.W. Huang, P.G. Halbur, X.J. Meng, T. Opriessnig. 2010. Comparison of commercial and experimental porcine circovirus type 2 (PCV2) vaccines using a triple challenge with PCV2, porcine reproductive and respiratory syndrome virus (PRRSV), and porcine parvovirus (PPV). Vaccine. 28(37):5960-5966.  

180. Cao D, Y.W. Huang, X.J. Meng. 2010. The nucleotides on the stem-loop RNA structure in the junction region of the hepatitis E virus (HEV) genome are critical for virus replication. Journal of Virology. 84(24):13040–13044. 

179. Huang Y.W., and X.J. Meng. (2010). Novel strategies and approaches to develop the next generation of vaccines against porcine reproductive and respiratory syndrome virus (PRRSV). Virus Research. 154:141-149. 

178. Opriessnig T, A.R. Patterson, D.M. Madson, N. Pal, S. Ramamoorthy, X.J. Meng, and P.G. Halbur. 2010. Comparison of the effectiveness of passive (dam) versus active (piglet) immunization against porcine circovirus type 2 (PCV2) and impact of passively derived PCV2 vaccine-induced immunity on vaccination. Veterinary Microbiology. 142(3-4):177-83. 

177. Huang YW, B.A. Dryman, K.K. Harrall, E.M. Vaughn, M.B. Roof, and X.J. Meng. 2010. Development of SYBR green-based real-time PCR and duplex nested PCR assays for quantification and differential detection of species- or type-specific porcine Torque teno viruses (TTV). Journal of Virological Methods. 170:140–146.

176. Ziemer CJ, Bonner JM, Cole D, Vinjé J, Constantini V, Goyal S, Gramer M, Mackie R, Meng XJ, Myers G, Saif LJ. 2010. Fate and transport of zoonotic, bacterial, viral, and parasitic pathogens during swine manure treatment, storage, and land application. Journal of Animal Sciences. 88(13 Suppl):E84-94.

175. Beach N.M., N.M. Juhan, L. Cordoba, and X.J. Meng. 2010. Replacement of the replication factors of porcine circovirus (PCV) type 2 with those of PCV type 1 greatly enhances viral replication in vitro. Journal of Virology. 84:8986-8989.

174. Hu J, Ni Y, Dryman BA, Meng XJ, Zhang C. 2010. Purification of porcine reproductive and respiratory syndrome virus from cell culture using ultrafiltration and heparin affinity chromatography. Journal of Chromatography A. 1217;3489–3493. 

173. Meng XJ. 2010. Recent advances in hepatitis E virus. Journal of Viral Hepatitis. 17; 153-161.  (Invited review).

172. Pavio N, X.J. Meng, and C. Renou. 2010. Zoonotic hepatitis E: animal reservoirs and emerging risks. Veterinary Research. 41 (6):46. doi: 10.1051/vetres/2010018

171. Huang YW, Y.Y. Ni, B.A. Dryman, and X.J. Meng. 2010. Multiple infection of porcine Torque teno virus in a single pig and characterization of the full-length genomic sequences of four U.S. prototype PTTV strains: Implication for genotyping of PTTV. Virology. 396:289-297.

170. Juhan NM, T. LeRoith, T. Opriessnig, and X.J. Meng. 2010. The open reading frame 3 (ORF3) of porcine circovirus type 2 (PCV2) is dispensable for virus infection but evidence of reduced pathogenicity is limited in pigs infected by a ORF3-null PCV2 mutant. Virus Research. 147:60-66.

169. Meng XJ. 2010. Hepatitis E virus: zoonotic risk and animal reservoirs. Veterinary Microbiology. 140:256-265.  

168. Madson DM, S. Ramamoorthy, C. Kuster, N. Pal, X.J. Meng, P.G. Halbur, T. Opriessnig. 2009. Infectivity of porcine circovirus type 2 DNA in semen from experimentally-infected boars. Veterinary Research. 40(1):10.  

167. Gillespie J, T. Opriessnig, X.J. Meng, K. Pelzer, and V. Maxwell. 2009. A review of Porcine circovirus type 2 and porcine circovirus associated disease. Journal of Veterinary Internal Medicine. 23(6):1151-63.

166. Beach N, R.B. Duncan, C.T. Larsen, X.J. Meng, N. Sriranganathan and F W Pierson. 2009. Persistent infection of turkeys with an avirulent strain of turkey hemorrhagic enteritis virus. Avian Diseases. 53(3):370-375.

165. Huang Y.W., Y. Fang, and X. J. Meng. 2009. Identification and characterization of a porcine monocytic cell line supporting porcine reproductive and respiratory syndrome virus (PRRSV) replication and progeny virion production by using an improved DNA-launched PRRSV reverse genetics system. Virus Research. 145:1–8.

164. Beach NM, Duncan RB, Larsen CT, X.J. Meng, Sriranganathan N, Pierson FW. 2009. Comparison of twelve Turkey hemorrhagic enteritis virus isolates allows for prediction of genetic factors affecting virulence. Journal of General Virology. 90:1978-1985.

163. Madson DM, Patterson AR, Ramamoorthy S, Pal N, X.J. Meng, and Opriessnig T. 2009. Effect of natural or vaccine-induced porcine circovirus type 2 (PCV2) immunity on fetal infection after artificial insemination with PCV2 spiked semen. Theriogenology. 72(6):747-54.  

162. Ramamoorthy S., F.F. Huang, Y.W. Huang, and X.J. Meng. 2009. Interferon-mediated enhancement of in vitro replication of porcine circovirus type 2 (PCV2) is influenced by an interferon stimulated response element in the PCV2 genome. Virus Research. 145:236-243.

161. Billam P., T. LeRoith, R.S. Pudupakam, F.W. Pierson, R.B. Duncan, and X.J. Meng. 2009. Comparative pathogenesis in specific-pathogen-free chickens of two strains of avian hepatitis E virus recovered from a chicken with Hepatitis-Splenomegaly syndrome and from a healthy chicken, respectively. Veterinary Microbiology. 139(3-4):253–261.

160. Huang YW, and X. J. Meng. 2009. Identification of a porcine DC-SIGN-related C-type lectin, porcine LSECtin, and its order of intron removal during splicing: Comparative genomic analyses of the CD23/LSECtin/DC-SIGN gene clusters among mammalian species. Developmental and Comparative Immunology. 33:747–760. 

159. Madson, DM, A.R. Patterson, S. Ramamoorthy, N. Pal, X.J. Meng, and T. Opriessnig. 2009. Effect of porcine circovirus type 2 (PCV2) vaccination of the dam on PCV2 replication in utero. Clinical and Vaccine Immunology. 16(6):830-834. 

158. Peralta B, M. Biarnés, G. Ordóñez, R. Porta, M. Martín, E. Mateu, S. Pina, X.J. Meng. 2009. Evidence of widespread infection of avian hepatitis E virus (avian HEV) in chickens from Spain. Veterinary Microbiology. 137(1-2):31-6.

157. Meng XJ, D.S. Lindsay, and N. Sriranganathan. 2009. Wild Boars as Sources for Infectious Diseases in Livestock and Humans. Philosophical Transactions of the Royal Society B (Biological Sciences). 364:2697-2707. 

156. Pudupakam RS, Y.W. Huang, P. Billam, S. Ramamoorthy, F.W. Pierson, and X.J. Meng. 2009. Deletions of the hypervariable region (HVR) in open reading frame 1 of hepatitis E virus do not abolish virus infectivity: evidence for attenuation of HVR deletion mutants in vivo. Journal of Virology. 83(1):384-95. 

155. Opriessnig T, A.R. Patterson, D.M. Madson, N. Pal, M. Rothschild, D. Kuhar, J. Lunney, N.M. Juhan, X.J. Meng, P.G. Halbur. 2009. Difference in severity of porcine circovirus type 2 (PCV2)-induced pathological lesions and diseases between selected Landrace and Pietrain pigs. Journal of Animal Sciences. 87(5):1582-90. 

154. Madson DM, Patterson AR, Ramamoorthy S, Pal N, Meng XJ, and Opriessnig T.  2009. Reproductive failure experimentally induced in sows via artificial insemination with semen spiked with porcine circovirus type 2 (PCV2). Veterinary Pathology. 46(4):707-16.

153. Opriessnig T., A. R. Patterson, D. Jones, N. M. Juhan, X. J. Meng, and P. G. Halbur. 2009. Limited susceptibility of three different mouse (Mus musculus) lines to porcine circovirus-2 infection and associated lesions. Canadian Journal of Veterinary Research. 73(2):81-86.

152. Huang YW, B. Dryman, and X.J. Meng. 2009. Porcine DC-SIGN: molecular cloning, gene structure, tissue distribution and binding characteristics. Developmental and Comparative Immunology. 33:464–480. 

151. Opriessnig T., A.R. Patterson, X.J. Meng, P.G. Halbur. 2009. Porcine circovirus type 2 in muscle and bone marrow is infectious and transmissible to naïve pigs by oral consumption. Veterinary Microbiology. 133(1-2):54–64. 

150. Ramamorthy S., and X.J. Meng. 2009. Porcine Circovirus: A Minuscule yet Mammoth Paradox. Animal Health Research Reviews. 10(1):1–20.   

149. Meng XJ. 2008. Hepatitis E Virus. In: Dana Cole and Jan Vinje (eds), Fate and Transport of Zoonotic Bacterial, Viral, and Parasitic Pathogens during Swine Manure: Treatment, Storage, and Land Application. National Pork Board (Special Publication no. 29. ISBN 978-1-887383-31-8), Des Moines, Iowa. pp 21-25.

148. Gillespie J, N.M. Juhan, J. DiCristina, K.F. Key, S. Ramamoorthy, and X.J. Meng. 2008. A genetically-engineered chimeric vaccine against porcine circovirus type 2 (PCV2) is genetically stable in vitro and in vivo. Vaccine. 26:4231–4236.

147. Meng XJ. 2008. Hepatitis E virus (hepevirus). Encyclopedia of Virology (5 vols), 3rd edition. B.W.J. Mahy and M.H.V. van Regenmortel (eds). Oxford: Elsevier. pp377-383. 

146. Billam P, F.W. Pierson, W. Li, T. LeRoith, R. Duncan, and X.J. Meng. 2008. Development and Validation of a Negative Strand-Specific RT-PCR Assay for Detection of a Chicken Strain of Hepatitis E Virus: Identification of Non-Liver Replication Sites. Journal of Clinical Microbiology. 46:2630-2634. 

145. Patterson AR, Johnson J, Ramamoorthy S, Meng XJ, Halbur PG, Opriessnig T. 2008. Comparison of three enzyme-linked immunosorbent assays to detect porcine circovirus type 2 (PCV2)-specific antibodies after vaccination or inoculation of pigs with distinct PCV1 or PCV2 isolates. Journal of Veterinary Diagnostic Investigation. 20(6):744-751. 

144. Opriessnig T, S. Ramamoorthy, D. Madson, A. Patterson, N. Pal, S. Carman, X.J. Meng, P.G. Halbur. 2008. Differences in virulence among porcine circovirus  type 2 isolates are unrelated to cluster type 2a or 2b and prior infection provides heterologous protection. Journal of General Virology. 89(10):2482-2491. 

143. Madson D.M., S. Ramamoorthy, C. Kuster, N. Pal, X.J. Meng, P.G. Halbur, T. Opriessnig. 2008. Characterization of shedding patterns of porcine circovirus type 2a and type 2b in experimentally inoculated mature boars. Journal of Veterinary Diagnostic Investigation. 20(6):725-34.

142. Feagins A.R., T. Opriessnig, Y.W. Huang, P. G. Halbur, and X.J. Meng. 2008. Cross-species infection of specific-pathogen-free pigs by a genotype 4 strain of human hepatitis E Virus. Journal of Medical Virology. 80(8):1379-1386.

141. Guo H., E.M. Zhou, Z.F. Sun, and X.J. Meng. 2008. Immunodominant epitopes mapped by synthetic peptides on the capsid protein of avian hepatitis E virus (avian HEV) are non-protective. Viral Immunology. 21(1):61-67.

140. N. Pal, Y.W. Huang, D.M. Madson, C. Kuster, X.J. Meng, P.G. Halbura, and T. Opriessnig. 2008. Development of a duplex real-time PCR assay for the simultaneous detection and quantification of porcine circovirus type 2 and an internal control on porcine semen samples. Journal of Virological Methods. 149:217-225.

139. Purkayastha A, Oswald Crasta, J. Dana Eckart, Michael Czar, X.J. Meng, Joan Setubal, Bruno Sobral (2008). Bioinformatics Resources for the Study of Viruses at the Virginia Bioinformatics Institute. In Structure-Based Study of Viral Replication. R.Holland Cheng, Tatsuo Miyamura eds. World Scientific Publishing Co. Pte. Ltd, Singapore/London-UK/Hackensack-NJ. pp.267-287.

138. Feagins AR, T. Opriessnig, D.K. Guenette, P.G. Halbur, and X.J. Meng. 2008. Inactivation of infectious hepatitis E virus in commercial pig livers. International Journal of Food Microbiology. 123:32-37.

137. Opriessnig T., Patterson AR, Elsener J, Meng XJ, Halbur PG.  2008. Influence of porcine circovirus type 2 (PCV2) maternal antibodies on efficacy of PCV2 vaccination to protect pigs from experimental infection with PCV2. Clinical and Vaccine Immunology. 15(3):397-401.

136. Matanin M, Y.W. Huang, X.J. Meng, and C. Zhang. 2008. Purification of the major envelop protein GP5 of porcine reproductive and respiratory syndrome virus (PRRSV) from native virions. Journal of Virological Methods. 147:127-135.

135. Patel D., T. Opriessnig, D.A. Stein, P.G. Halbur, X.J. Meng, P.L. Iversen, and Y.-J. Zhang. 2008. Arginine-rich Cell Penetrating Peptide-conjugated Morpholino Oligomers Inhibit Porcine Reproductive and Respiratory Syndrome Virus Replication in vitro. Antiviral Research. 77:95-107.

134. Zhou E, Guo H., F. F. Huang, Z. F. Sun, X.J. Meng. 2008. Identification of two neutralization epitopes on the capsid protein of avian hepatitis E virus (avian HEV) by epitope mapping. Journal of General Virology. 89(2):500-508.

133. Meng XJ, HL Shivaprasad, and C Payne. 2008. Hepatitis E virus infections. In: M. Saif et al (eds) Diseases of Poultry, 12th Edition. Blackwell Publishing Press.  pp. 443-452.

132. Thomas PJ, T. Opriessnig, Juhan NM, Meng XJ, Halbur PG. 2007. Planned exposure through serum injection is not effective in preventing porcine circovirus type 2 (PCV2) infection and PCV2 associated disease (PCVAD) and lesions. Journal of Swine Health and Production. 15(6):330-338. 

131. Oprissnig T, X.J. Meng, and P.G. Halbur. 2007. Porcine circovirus type 2 associated disease (PCVAD): Update on current terminology, clinical manifestations, pathogenesis, diagnosis, and intervention strategies. Journal of Veterinary Diagnostic Investigation. 19(6):591-615. 

130. Key KF, DiCristina J, Gillespie J, Guenette DK, and X.J. Meng.  2007. Direct inoculation of RNA transcripts from an infectious cDNA clone of porcine reproductive and respiratory syndrome virus (PRRSV) into the lymph nodes and tonsils of pigs initiates PRRSV infection in vivo.  Archives of Virology. 152:1383-1387. 

129. Guo H., E. M. Zhou, Z. F. Sun, and X.J. Meng. 2007. Egg whites from eggs of chickens infected experimentally with avian hepatitis E virus contain infectious virus, but evidence of complete vertical transmission is lacking. Journal of General Virology. 88:1532-1537. 

128. Martín M., J. Segalés, F.F. Huang, D.K. Guenette, E. Mateu, N. de Deus, and X.J. Meng.  2007. Association of hepatitis E virus (HEV) and postweaning multisystemic wasting syndrome (PMWS) with lesions of hepatitis in pigs. Veterinary Microbiology. 122:16-24. 

127. Billam P, Sun ZF, and Meng XJ. 2007. Analysis of the complete genomic sequence of an apparently avirulent strain of avian hepatitis E virus (avian HEV) identified major genetic differences compared with the prototype pathogenic strain of avian HEV. Journal of General Virology. 88:1538-1544 

126. Huang YW, Oprissnig T, Halbur PG, and Meng XJ.  2007.  Initiation at the third in-frame AUG codon of open reading frame 3 of the hepatitis E virus is essential for viral infectivity in vivoJournal of Virology. 81:3018-3026. 

125. Feagins A.R., T. Opriessnig, D.K. Guenette, P.G. Halbur, and X.J. Meng. 2007. Detection and characterization of infectious hepatitis E virus from commercial pig livers sold in local grocery stores in the United States. Journal of General Virology. 88(3):912-917.

124. Guo H, E.M. Zhou, Z.F. Sun, and X.J. Meng. 2007. Protection of chickens against avian hepatitis E virus (avian HEV) infection by immunization with recombinant avian HEV capsid protein. Vaccine. 25:2892-9.

123. Snyder. E.E., Kampanya, N., Lu, J., Nordberg, E., Rajasimha, H.K., Shukla, M., Soneja, J., Tian, Y., Xue, T., Yoo, H., Zhang, F., Dharmanolla, C., Dongre, N.V., Gillespie, J., Hamelius, J., Hance, M., Huntington, K., Jukneliene, D., Koziski, J., Mackasmiel, L., Mane, S.P., Nguyen, V., Purkayastha, A., Shallom, J., Yu, G., Gabbard, J., Hix, D., Azad, A., Baker, S., Boyle, S., Khudyakov, Y., Meng, X.J., Rupprecht, C., Vinje, J., Crasta, O.R., Czar, M.J., Dickerman, A., Eckart, J.D., Kenyon, R., Will, R., Setubal, J.C. and Sobral, B.  2007.  PATRIC: The VBI PathoSystems Resource Integration Center. Nucleic Acids Research. 35:D401-6.

122. Opriessnig T, N.E. McKeown, E. Zhou, X.J. Meng, P.G. Halbur (2006). Genetic and experimental comparison of porcine circovirus type 2 (PCV2) isolates from cases with and without PCV2-associated lesions provides evidence for differences in virulence. Journal of General Virology. 87(10):2923-2932.

121. Opriessnig T., N.E. McKeown, K.L. Harmon, X.J. Meng, and P.G. Halbur (2006). Porcine circovirus type-2 infection decreases the efficacy of a modified live porcine reproductive and respiratory syndrome virus vaccine. Clinical and Vaccine Immunology. 13:923-929.

120. Zhang Y, Stein DA, Fan SM, Wang KY, Kroeker AD, X.J. Meng, Iversen PL, and Matson DO. 2006.  Suppression of porcine reproductive and respiratory syndrome virus replication by morpholino antisense oligomers. Veterinary Microbiology.  117:117-129.  

119. Opriessnig T., M. Fenaux, P. Thomas, M. J. Hoogland, R. B. Evans, M. F. Rothschild,  X.J. Meng, and P. G. Halbur (2006). Evidence of breed-dependent differences in susceptibility to porcine circovirus type 2-associated disease and lesions. Veterinary Pathology. 43:281-293. 

118. Opriessnig, T., P. G. Halbur, S. Yu, E. L. Thacker, M. Fenaux, and X.J. Meng (2006). Effects of the timing of administration of Mycoplasma hyopneumnia bacterin on development of lesions associated with porcine circovirus type 2. Veterinary Record. 158:149-154.

117. Jothikumar N. J., T. Cromeans, B. Robertson, X.J. Meng, and V.R. Hill1 (2006). A broadly reactive one step real-time RT-PCR assay for rapid and sensitive detection of hepatitis E virus (HEV). Journal of Virological Methods. 131:65-71.

116. Guo H., E. M. Zhou, Z. F. Sun, XJ Meng, and P.G. Halbur. 2006. Identification of B cell epitopes in the capsid protein of avian hepatitis E virus (avian HEV) that are common to human and swine HEVs or unique to avian HEV. Journal of General Virology. 87:217-223. 

115. Meng X.J., and P.G. Halbur (2006). Porcine lymphotropic herpesviruses. In: B.E. Straw et al (eds): Diseases of Swine, 9th Edition.  pp.550-554.  Blackwell Publishing Press.

114. Meng X.J., and P.G. Halbur (2006). Swine hepatitis E virus. In: B.E. Straw et al (eds): Diseases of Swine, 9th Edition. Blackwell Publishing Press. pp.537-545. 

113. Meng X.J., C.A. Baldwin, F. Elvinger, P.G. Halbur, and C.A. Wilson (2006). In: B.E. Straw et al (eds): Miscellaneous viral infections. Diseases of Swine, 9th Edition. Blackwell Publishing Press. pp.537-560.

112. Meng XJ (2005). Hepatitis E as a zoonosis. Viral Hepatitis, 3rd edition, Edited by H. Thomas, A. Zuckermann, and S. Lemon. pp611-623. Blackwell Publishing Ltd, Oxford, U.K.

111. Huang FF, Pierson FW, Toth TE, and XJ Meng (2005). Construction and characterization of infectious cDNA clones of a chicken strain of hepatitis E virus (HEV), avian HEV. Journal of General Virology. 86:2585-2593. 

110. McKeown NE, T. Opriessnig, P. Thomas, D. K. Guenette, F. Elvinger, M. Fenaux, P.G. Halbur, and X.J. Meng.  2005. Effects of type 2 porcine circovirus (PCV2) maternal antibodies on experimental infection of piglets with PCV2. Clinical and Diagnostic Laboratory Immunology. 12:1347-1351.

109. Kasorndorkbua C, Opriessnig T, Huang F.F., Guenette D.K., Thomas P.J., X.J. Meng, and P.G. Halbur (2005). Infectious swine hepatitis E virus is present in pig manure storage facilities on United States farms, but evidence of water contamination is lacking. Applied and Environmental Microbiology. 71:7831-7837.

108. Cooper K., F.F. Huang, L. Batista, C.D. Rayo, J.C. Bezanilla, T.E. Toth, and X. J. Meng (2005).  Identification of genotype 3 hepatitis E virus (HEV) in serum and fecal samples from pigs in Thailand and Mexico, where genotype 1 or 2 HEV strains are prevalent in respective human populations. Journal of Clinical Microbiology. 43:1684-1688. 

107. Billam P., F.F. Huang, Z.F. Sun, F.W. Pierson,  R.B. Duncan, F. Elvinger, D.K. Guenette, T.E. Toth, and X. J. Meng (2005). Systematic pathogenesis and replication of avian hepatitis E virus in specific-pathogen-free adult chickens. Journal of Virology. 79:3429-37.

106. Meng X.J. (2005). Hepatitis E virus: Cross-species infection and zoonotic risk. Clinical Microbiology Newsletter. 26:43-48.   

105. Huang Y.W., G. Haqshenas, C. Kasorndorkbua, P. G. Halbur, S. U. Emerson, X. J. Meng (2005). Capped RNA transcripts of full-length cDNA clones of swine hepatitis E virus are replication-competent when transfected into Huh7 cells and infectious when intrahepatically inoculated into pigs. Journal of Virology. 79:1552-1558.

104. Emerson, S.U., Anderson, D., Arankalle, A., X.J. Meng, Purdy, M., Schlauder, G.G. and Tsarev, S.A. (2004).  Hepevirus.  In: Virus Taxonomy, VIIIth Report of the ICTV.  Fauquet C.M., M.A. Mayo, J. Maniloff, U. Desselberger, and L.A. Ball (eds), Elsevier/Academic Press, London. pp851-855.

103. Fenaux M., T. Opriessnig, P. G. Halbur, Y. Xu, B. Potts, and X. J. Meng (2004). Detection and in vitro and in vivo characterizations of porcine circoviruses from porcine-derived commercial pepsin product.  Journal of General Virology. 85:3377-3382.

102. Kasorndorkbua C., D. K. Guenette, F. F. Huang, P. J. Thomas, X.J. Meng, and P. G. Halbur (2004). Routes of transmission of swine hepatitis E virus in pigs.  Journal of Clinical Microbiology. 42:5047-5052.

101. Fenaux M, T. Opriessnig, P.G. Halbur, F. Elvinger, and X.J. Meng (2004). Two amino acid mutations in the capsid protein of type 2 porcine circovirus (PCV2) enhanced PCV2 replication in vitro and attenuated the virus in vivoJournal of Virology 78:13440-13446.

100. McKeown N.E., M. Fenaux, P.G. Halbur, X.J. Meng (2004). Molecular characterization of porcine TT virus, an orphan virus, in pigs from six different countries. Veterinary Microbiology.  104:113-117.

99. Opriessnig T., E.L. Thacker, S. Yu, M. Fenaux, X.J. Meng, P. G. Halbur (2004). Experimental reproduction of postweaning multisystemic wasting syndrome in pigs by dual infection with Mycoplasma hyopneumoniae and porcine circovirus type 2. Veterinary Pathology. 41(6):624-640.

98. Lekcharoensuk P, I. Morozov, P.S. Paul, N. Thangthumniyom, W. Wajjawalku, and X.J. Meng (2004). Epitope mapping of the major capsid protein of type 2 porcine circovirus (PCV2) using chimeric PCV1 and PCV2 viruses. Journal of Virology. 78:8135-8145.

97. Sun Z.F., C.T. Larsen, F. F. Huang, P. Billam, F. W. Pierson, T. E. Toth, and X.J. Meng (2004). Generation and infectivity titration of an infectious stock of avian hepatitis E virus (HEV) in chickens and cross-species infection of turkeys with avian HEV. Journal of Clinical Microbiology42:2658-2662. 

96. Sun Z.F., and X.J. Meng (2004). Antigenic cross-reactivity between the nucleocapsid protein of SARS-coronavirus and polyclonal antisera of antigenic group I animal coronaviruses: Implication for SARS diagnosis. Journal of Clinical Microbiology. 42:2351-2352.

95. Fenaux M, T. Opriessnig, P.G. Halbur, F. Elvinger, and X.J. Meng (2004). A chimeric porcine circovirus (PCV) with the immunogenic capsid gene of the pathogenic PCV2 cloned into the genomic backbone of the non-pathogenic PCV1 induces protective immunity against PCV2 infection in pigs. Journal of Virology 78:6297-6303. 

94. Huang FF, Z.F. Sun, S.U. Emerson, R.H. Purcell, H.L. Shivaprasad, F.W. Pierson, T.E. Toth, and X.J. Meng (2004). Determination and analyses of the complete genomic sequence of avian hepatitis E virus and attempts to experimentally infect rhesus monkeys with avian HEV. Journal of General Virology. 85:1609-1618. 

93. Sun ZF, C. Larsen, A. Dunlop, F. Huang, F. Pierson, T. Toth, and X.J. Meng (2004). Genetic identification of avian hepatitis E virus (avian HEV) from healthy chicken flocks and characterization of the capsid gene of 14 avian HEV isolates from chickens with hepatitis-splenomegaly syndrome in different geographic regions of the United States. Journal of General Virology. 85:693-700. 

92. Opriessnig T, M. Fenaux, J. M. Gallup, S. Yu, R. B. Evans, D. Cavanaugh, F. J. Pallares, M. R. Ackermann, E. Thacker, K. M. Lager, X.J. Meng, and P. G. Halbur  (2004).  Effect of porcine parvovirus vaccination on the development of PMWS in segregated early weaned pigs coinfected with type 2 porcine circovirus and porcine parvovirus. Veterinary Microbiology. 98:209-220.

91. Fenaux, M., T. Opriessnig, P.G. Halbur, X.J. Meng (2003). Immunogenicity and pathogenicity of the chimeric infectious DNA clones between pathogenic type 2 porcine circovirus (PCV2) and non-pathogenic PCV1 in weaning pigs. Journal of Virology. 77:11232-11243. 

90. Key, K.F., D.K. Guenette, K.J. Yoon, P.G. Halbur, T.E. Toth, and X.J. Meng (2003). Development of a heteroduplex mobility assay to identify field isolates of porcine reproductive and respiratory syndrome virus with nucleotide sequences closely related to those of modified live-attenuated vaccines. Journal of Clinical Microbiology41:2433 -2439.

89. Kasorndorkbua, C., B.J. Thacker, P.G. Halbur, D.K. Guenette, R. Beitenwerf, R. L. Royer, and X.J. Meng (2003). Experimental infection of swine hepatitis E virus in pregnant gilts.  Canadian Journal of Veterinary Research. 67:303-306.

88. Opriessnig T, Yu S, Gallup J.M., Evans R.B., Fenaux M, Pallares F, Thacker E.L., Brockus C.W., Ackermann M.R., Thomas P, Meng X.J., and Halbur P.G. (2003). Effect of vaccination with selective bacterins on conventional pigs infected with type 2 porcine circovirus. Veterinary Pathology. 40:521-529.

87. Sun, Z.F., F.F. Huang, P.G. Halbur, S.K. Schommer, F.W. Pierson, T.E. Toth, and X.J. Meng (2003).  Use of heteroduplex mobility assays (HMA) for pre-sequence screening and identifications of variant strains of avian and swine hepatitis E viruses. Veterinary Microbiology. 96:165-176.

86. Meng, X.J. (2003). Swine hepatitis E virus: cross-species infection and risk in xenotransplantation. Current Topics in Microbiology and Immunology. 278:185-216.

85. Engle RE, Yu C, Emerson SU, Meng XJ, and Purcell RH (2002).  Hepatitis E virus (HEV) capsid antigen derived from virus of human or swine origin is equally efficient for detecting anti-HEV by enzyme immunoassay. Journal of Clinical Microbiology. 40:4576-4580.

84. Opriessnig T., P.G. Halbur, K.J. Yoon, R.M. Pogranichniy, E.M. Vaughn, K.M. Harmon, R.Evans, K.F. Key, F.J. Pallares, P. Thomas, X.J. Meng (2002).  Comparison of molecular and biological characteristics of a modified live PRRSV vaccine (RespPRRS/Repro™), the parent strain of the vaccine (ATCC VR2332), ATCC VR2385, and two recent field isolates of PRRSV. Journal of Virology. 76:11837-11844.

83. Huang FF, Haqshenas G, Shivaprasad HL, Guenette DK, Woolcock PR, Larsen CT, Pierson FW, Elvinger F, Toth TE, and Meng XJ. (2002).  Heterogeneity and seroprevalence of the newly-identified avian hepatitis E virus from chickens in the United States. Journal of Clinical Microbiology. 40:4197-4202.

82. Halbur PG, Pallares FJ, Rathje JA, Evans R, Hagemoser WA, Paul PS, and X.J. Meng (2002). Effects of different U.S. isolates of porcine reproductive and respiratory syndrome virus (PRRSV) on blood and bone marrow parameters of experimentally infected pigs. Veterinary Record. 151(12):344-348.

81. Huang, F.F., G.Haqshenas, D.K. Guenette, P.G. Halbur, S.Schommer, F.W. Pierson, T.E. Toth and X.J. Meng (2002).  Detection by RT-PCR and genetic characterization of field isolates of swine hepatitis E virus from pigs in different geographic regions of the U.S. Journal of Clinical Microbiology. 40:1326-1332. 

80. Haqshenas G., F.F. Huang, M. Fenaux, D.K. Guenette, F.W. Pierson, H.L. Shivaprasad, T.E. Toth  and X.J. Meng (2002). The putative capsid protein of the newly identified avian hepatitis E virus shares antigenic epitopes with that of swine and human hepatitis E viruses and the chicken big liver and spleen disease virus.  Journal of General Virology. 83:2201-2209.

79.  Fenaux, M., P.G. Halbur, G. Haqshenas,  R. Royer, P. Nawagitgul,  M. Gill,  T.E. Toth, and X.J. Meng (2002).  The cloned genomic DNA of the type-2 porcine circovirus (PCV-2) is infectious when injected into the liver and lymph nodes of SPF pigs: characterization of clinical course, virus distribution and pathological lesions. Journal of Virology. 76:541-551.

78. Kasorndorkbua, C., P.G. Halbur, D.K. Guenette, T.E. Toth, X.J. Meng (2002). Use of a swine bioassay and a RT-PCR assay to assess the risk of transmission of swine hepatitis E virus in pigs. Journal of Virological Methods. 101:71-78.

77. Wu, J.C., CM Chen, TY Chiang, WH Tsai, WJ Jeng, IJ Sheen, JY Chen, CC Lin, X.J. Meng (2002). Spread of Hepatitis E Virus among Different-aged Pigs: A Two-year Survey in Taiwan. Journal of Medical Virology. 66:488-492.

76.  Inzana, T.J., D.S. Lindsay, X.J. Meng, and K.W. Post (2002). Commercial Methods in Clinical Veterinary Microbiology. In: Manual of Commercial Methods in Clinical Microbiology. American Society for Microbiology Press, Washington, DC. pp. 336-359. 

75. Meng XJ, Wiseman B, Elvinger F, Guenette DK, Toth TE, Engle RE, Emerson SU, Purcell RH. (2002). Prevalence of antibodies to the hepatitis E virus in veterinarians working with swine and in normal blood donors of the United States and other countries. Journal of Clinical Microbiology.  40:117-122.

74. Emerson SU, Zhang M, Meng X.J., St. Clair M, Nguyen H, Huang Y, and Purcell RH (2001). Recombinant hepatitis E virus genomes infectious for primates: importance of capping and discovery of a cis-reactive element. Proceedings of the National Academy of Sciences USA 98:15270-15275.

73. Haqshenas G. and X.J. Meng (2001). Determination of the nucleotide sequences of the extreme 3' and 5' ends of the swine hepatitis E virus genome. Archives of Virology. 146:2461-2467.

72. Williams, T., Kasorndorkbua C., Halbur P.G., Guenette D., Toth T.E., X.J. Meng (2001). Evidence for extrahepatic sites of replication of the hepatitis E virus in a swine model. Journal of Clinical Microbiology. 39:3040-3046.

71. Key, K.F., Haqshenas G, Guenette D., S.L. Swenson, T.E. Toth, X.J. Meng (2001). Genetic characterization of the major envelope gene of acute porcine reproductive and respiratory syndrome virus isolates. Veterinary Microbiology. 83:249-263.

70. Haqshenas, G., H.L. Shivaprasad, P. Woolcock, D. Read, X.J. Meng (2001). Genetic identification and characterization of a novel virus related to human hepatitis E virus from chickens with hepatitis-spleenomegaly syndrome. Journal of General Virology. 82:2449-2462.

69. Halbur, P.G., C. Kasorndorkbua, C. Gilbert, D. Guenette, M. B. Potters, R. H. Purcell, S. U. Emerson, T.E. Toth, X.J. Meng (2001).  Comparative pathogenesis of infections of growing pigs with hepatitis E viruses recovered from a swine and a human. Journal of Clinical Microbiology. 39:918-923. 

68. Meng, X.J. (2000).  Heterogeneity of porcine reproductive and respiratory syndrome virus: implications for current vaccine efficacy and future vaccine development. Veterinary Microbiology. 74:309-329.

67. Meng, X.J (2000).  Novel strains of hepatitis E virus identified from humans and other animal species: Is hepatitis E a zoonosis? Journal of Hepatology 33:842-845.

66. Fenaux, M., P.G. Halbur, M. Gill, T.E. Toth, and X.J. Meng (2000). Genetic characterization of type-2 porcine circovirus (PCV-2) from pigs with PMWS in different geographic regions of North America and development of a differential PCR-RFLP assay to detect and differentiate infections between PCV-1 and PCV-2. Journal of Clinical Microbiology. 38:2494-2503. 

65. Meng, X.J. (2000). Zoonotic and xenozoonotic risks of the hepatitis E virus. Infectious Disease Review. 2:35-41.

64. Meng, X.J., S. Dea, R.E. Engle, R. Friendship, Y.S. Lyoo, T. Sirinarumitr, K. Urairong, D. Wang, D. Wong, D. Yoo, Y. Zhang, R.H. Purcell, and S.U. Emerson (1999).  Prevalence of antibodies to the hepatitis E virus (HEV) in pigs from countries where hepatitis E is common or rare in the human population. Journal of Medical Virology. 59:297-302.

63. Kabrane-Lazizi, Y., X.J. Meng, R.H. Purcell, and S.U. Emerson. Evidence that the genomic RNA of hepatitis E virus is capped (1999). Journal of Virology. 73:8848-8850.

62. Hsieh, S.-Y., X.J. Meng, Y.-H. Wu, A.W. Tam, S.-T. Liu, D.-Y. Lin, and Y.-F. Liaw (1999).  Identity of a novel swine hepatitis E virus in Taiwan forming a monophyletic group with the Taiwan isolates of human hepatitis E virus. Journal of Clinical Microbiology. 37:3828-3834.

61. Kabrane-Lazizi, Y., J.B. Fine, J. Elm, G.E. Glass, H. Higa, A. Diwan, C.J. Gibbs Jr, X.J. Meng, S.U. Emerson, R.H. Purcell (1999). Evidence for wide-spread infection of wild rats with hepatitis E virus in the United States. American Journal of Tropical Medicine and Hygiene. 61:331-335.

60. Meng, X.J., P.G. Halbur, M. Shapiro, S. Govindarajan, J.D. Bruna, I. K. Mushahwar, R.H. Purcell, and S.U. Emerson (1998). Genetic and experimental evidence for cross-species infection by the swine hepatitis E virus. Journal of Virology. 72:9714-9721.

59. Halbur, P.G., M. Rothschild, B.J. Thacker, X.J. Meng, P.S. Paul, J. D. Bruna. (1998). Differences in susceptibility of Duroc, Hampshire, and Meishan pigs to infection with a high virulence strain (VR2385) of porcine reproductive and respiratory syndrome virus (PRRSV). Journal of Animal Breedings and Genetics. 115:181-189.

58. Meng, X.J., P.G. Halbur, J.S. Haynes, T.S. Tsareva, J.D. Bruna, R.D. Royer, R.H. Purcell, and S.U. Emerson (1998). Experimental infection of pigs with the newly identified swine hepatitis E virus (swine HEV), but not with human strains of HEV. Archives of Virology. 143:1405-1415. 

57. Meng, X.J., R.H. Purcell, P.G. Halbur, J.R. Lehman, D.M. Webb, T.S. Tsareva, J.S. Haynes, B.J. Thacker, and  S.U. Emerson (1997). A novel virus in swine is closely related to the human hepatitis E virus. Proceedings of the National Academy of Sciences USA 94:9860-9865.

56. Haynes, J.S., P.G. Halbur, T. Sirinarumitr, P. S. Paul, X.J. Meng, and E. L. Huffman (1997). Temporal and morphologic characterization of the distribution of porcine reproductive and respiratory syndrome virus (PRRSV) by in situ hybridization in pigs infected with isolates of PRRSV that differ in virulence. Veterinary Pathology 34:39-43. 

55. Meng, X.J., P.S. Paul, P.G. Halbur, and M.A. Lum (1996). Characterization of a high virulence U.S. isolate of porcine reproductive and respiratory syndrome virus in a continuous cell line, ATCC CRL11171. Journal of Veterinary Diagnostic Investigation 8:374-381. 

54. Meng, X.J., P.S. Paul, I. Morozov, and P.G. Halbur (1996). A nested set of six or seven subgenomic mRNAs is formed in cells infected with different isolates of porcine reproductive and respiratory syndrome virus. Journal of General Virology 77:1265-1270.

53. Halbur, P.G., P.S. Paul, X.J. Meng, M.A. Lum, and J.A. Rathje (1996). Comparative pathogenicity of nine U.S. porcine reproductive and respiratory syndrome virus (PRRSV) isolates in a 5 week-old cesarean-derived-colostrum-deprived pig model. Journal of Veterinary Diagnostic Investigation 8:11-20.

52. Halbur, P.G., P.S. Paul, M.L. Frey, J. Landgraf, K. Eernisse, X.J. Meng, J.J. Andrews, M.A. Lum, and J.A. Rathje (1996). Comparison of the antigen distribution of two U.S. porcine reproductive and respiratory syndrome virus isolates with that of the Lelystad virus. Veterinary Pathology  33:159-170.

51. Meng, X.J., P.S. Paul, P.G. Halbur, and I. Morozov (1995).  Sequence comparison of open reading frames 2 to 5 of low and high virulence U. S. isolates of porcine reproductive and respiratory syndrome viruses. Journal of General Virology 76:3181-3188.

50. Halbur, P.G., P.S. Paul, M.L. Frey, J. Landgraft, K. Eernisse, X.J. Meng, M.A. Lum, J.J. Andrews, and J.A. Rathje (1995). Comparison of the pathogenicity of two U.S. porcine reproductive and respiratory syndrome virus isolates with that of the Lelystad virus. Veterinary Pathology 32:648-660.

49. Meng, X.J., P.S. Paul, P.G. Halbur, and M.A. Lum (1995). Phylogenetic analyses of the putative M (ORF 6) and N (ORF 7) genes of porcine reproductive and respiratory syndrome virus (PRRSV):  implication for the existence of two genotypes of PRRSV in the U.S.A. and Europe. Archives of Virology 140:745-755.

48. Morozov, I., X.J. Meng, P.S. Paul (1995). Sequence analysis of open reading frames (ORF) 2 to 4 of the porcine reproductive and respiratory syndrome virus (PRRSV). Archives of Virology  140:1313-1319. 

47.  Halbur, P.G., L.D. Miller, P.S. Paul, X.J. Meng, E.L. Huffman, and J.J. Andrews (1995).  Immunohistochemical identification of porcine reproductive and respiratory syndrome virus (PRRSV) antigen in the heart and lymphoid system of three-week-old colostrum-deprived pigs. Veterinary Pathology 32:200-204.

46.  Meng, X.J., P.S. Paul, and P.G. Halbur (1994).  Molecular cloning and nucleotide sequencing of the 3' terminal genomic RNA of porcine reproductive and respiratory syndrome virus. Journal of General Virology 75:1795-1801.

45. Halbur, P.G., J.J. Andrews, E.L. Huffman, P.S. Paul, X.J. Meng, and Y. Niyo (1994).  Development of a streptavidin-biotin immunoperoxidase procedure for the detection of porcine reproductive and respiratory syndrome virus antigen in porcine lung. Journal of Veterinary Diagnostic Investigation 6:254-257.

44. Meng, X.J., P.S. Paul, E.M. Vaughn, and J.J. Zimmerman (1993).Development of a radiolabeled nucleic acid probe for the detection of encephalomyocarditis virus infection in swine. Journal of Veterinary Diagnostic Investigation 5:254-258.

 

Award Winning Lab Members

  • 2024: Bo Wang received the Journal "Viruses" 2024 Award for Postdoctoral Researchers, March 2024.
  • 2024: Anna Hassebroek is the winner of the VMCVM Phi Zeta Manuscript Competition in Basic Science, March 2024.
  • 2023: Anna Hassebroek received the 2023 Boehringer Ingelheim Research Award for Graduate Veterinarians.
  • 2023: Anna Hassebroek received the 2023 ASV Travel Award to present her work at the 2023 Annual Meeting of the American Society for Virology, Athens, GA.
  • 2023: Bo Wang received the 2023 Postdoctoral Research Award from the Conference of Research Workers in Animal Diseases (CRWAD), sponsored by the CRWAD Council and Program Committee, in Chicago, IL
  • 2022: C. Lynn Heffron received 2022 President’s Award for Excellence from Virginia Tech.
  • 2022: Bo Wang, Postdoctoral ASV Travel Award, to present his research at the 2022 Annual meeting of the American Society of Virology, Madison, WI.
  • 2022: Hassan Mahsoub, Postdoctoral ASV Travel Award, to present his research at the 2022 Annual meeting of the American Society of Virology, Madison, WI.
  • 2018: Nicholas Catanzaro received a graduate student travel fellowship from 2018 International PRRS Symposium and 2018 IPVS to attend the International PRRS Symposium in Chongqing, China. June 2018.
  • 2017: Harini Sooryanarain, Postdoctoral ASV Travel Award, to present her research at the 2017 Annual meeting of the American Society of Virology, Madison, WI.
  • 2017: C. Lynn Heffron received Staff of the Month award from the Virginia-Maryland College of Veterinary Medicine.
  • 2016: Nicholas Catanzaro received a USDA NIFA graduate fellowship award ($95,000) for his PhD dissertation research on PRRSV. Dec 2016.
  • 2016: Caitlin Cossaboom won the university’s Outstanding Dissertation Award. Virginia Tech, March 2016.
  • 2015: Qian M. Cao won outstanding graduate student presentation award by the American College of Veterinary Microbiologists at the 96th Annual Meeting of the Conference for Research Workers in Animal Diseases. Dec 5-7, 2015, Chicago, IL.
  • 2015: Qian M. Cao won a GSA Travel Award to present her work at 2015 Conference for Research Workers in Animal Diseases. Dec 6-8, 2015.
  • 2014: Danielle Yugo won a Graduate Student Travel Award to present her research on hepatitis E virus at the 2014 American Society for Virology 33rd annual meeting at the Colorado State University, Ft Collins, CO. June 21-25, 2014.
  • 2013: C. Lynn Heffron received Outstanding Co-Worker Recognition Award from the Virginia-Maryland College of Veterinary Medicine.
  • 2013: Yanyan Ni named the VMCVM Outstanding Doctoral Student, Virginia Tech, 2014.
  • 2013: Yanyan Ni won the Outstanding PhD Student Presentation Award at the 24th VMCVM Annual Research Symposium. March 21, 2013.
  • 2012: Pablo Piñeyro won the 2012 Charles Louis Davis D.V.M. Foundation for the Advancement of Veterinary and Comparative Pathology Student Scholarship Award in Veterinary Pathology.
  • 2012: Yanyan Ni won the Don Kahn Award (Best Overall Graduate Student Presentation Award) from the American College of Veterinary Microbiologists at the 93rd Annual Meeting of the Conference for Research Workers in Animal Diseases. Dec 2-3, 2012, Chicago, IL.
  • 2011: Yanyan Ni won the Outstanding Ph.D. Student Presentation Award at the 23rd VMCVM Annual Research Symposium. September 30, 2011.
  • 2011: Nathan Beach won a Postdoctoral Travel Award to present his research on porcine circovirus at the 2011 American Society for Virology 30th Annual Meeting at the University of Minnesota, Minneapolis, July 16-20th, 2011.
  • 2011: Scott Kenney won a Postdoctoral Travel Award to present his research on hepatitis E virus at the 2011 American Society for Virology 30th Annual Meeting at the University of Minnesota, Minneapolis, July 16-20th, 2011.
  • 2011: Caitlin Cossaboom won a Graduate Student Travel Award to present her research on rabbit hepatitis E virus at the 2011 American Society for Virology 30th annual meeting at the University of Minnesota, Minneapolis, July 16-20th, 2011.
  • 2011: R.S. “Sumanth” "Pudupakam won a Graduate Student Travel Award to present his research on hepatitis E virus at the 2011 American Society for Virology 30th annual meeting at the University of Minnesota, Minneapolis, July 16-20th, 2011.
  • 2010: Sara Smith won the best M.S. graduate student presentation award (oral presentation) at the 22nd VMCVM Annual Research Symposium, Nov. 19th, 2010.
  • 2009: Alicia Feagins won the first place graduate student award (oral presentation) at the 21rst VMCVM Annual Research Symposium, November 20, 2009.
  • 2009: R.S. “Sumanth” Pudupakam won a second place graduate student award (poster presentation) at the 21rst VMCVM Annual Research Symposium, Nov 20, 2009.
  • 2007: Jennifer Gillespie won a second place graduate student award (oral presentation) at the 19th VMCVM Annual Research Symposium, May 21-22, 2007.
  • 2007: Alicia Feagins won a Graduate Student Travel Award to present her research on hepatitis E virus at the American Society for Virology 26th annual meeting at Oregon State University, Corvallis, Oregon, July 14-18, 2007.
  • 2006: Kijona F. Key won the best graduate student presentation award by the American College of Veterinary Microbiologists at the at the 87th Annual Meeting of the Conference of Research Workers in Animal Diseases in Chicago, IL, Dec. 1-3, 2006.
  • 2006: Alicia Feagins won a third place graduate student award (Basic Science Category) at the 18th VMCVM Annual Research Symposium, May 23-24, 2006.
  • 2006: Nicole McKeown won a Graduate Student Travel Award to present her research on porcine circovirus at the 2006 American Society for Virology 25th annual meeting at Madison, Wisconsin, July 15-19, 2006.
  • 2006: Padma Billam won a Graduate Student Travel Award to present her research on avian hepatitis E virus at the 2006 American Society for Virology 25th annual meeting at Madison, Wisconsin, July 15-19, 2006.
  • 2005: Martijn Fenaux won the University Outstanding Dissertation Award, Virginia Tech. March 24, 2005.
  • 2005: Padma Billam won the first place award at the 56th Annual Meeting of Animal Diseases Research Workers in Southern States. Blacksburg, VA. April 7, 2005.
  • 2005: Fang-Fang Huang won a Postdoctoral Travel Award to the 2005 ASV 24th annual meeting at The Pennsylvania State University, University Park, PA, June 18-22.
  • 2005: Yao-Wei Huang won a Postdoctoral Travel Award to the 2005 ASV 24th annual meeting at The Pennsylvania State University, University Park, PA, June 18-22.
  • 2005: Padma Billam won a Graduate Student Travel Award to present her research on hepatitis E virus at the ASV 24th annual meeting at University Park, PA, June 18-22.
  • 2005: Kijona Key won the Auxiliary to the American Veterinary Medical Association Award, VMCVM, May 2005.
  • 2004: Nicole McKeown won the first place award (Agricultural, Animal Sciences and Vet. Med. category) at 20th Annual Graduate Research Symposium of VA Tech, March 23, 2004.
  • 2004: Fang-Fang Huang won the first place graduate student award (Basic Science Category) at the 16th VMCVM Annual Research Symposium, June 17-18, 2004.
  • 2004: Kerri Cooper won the first place award (Biosafety and Biosecurity Category) sponsored by The Animal Health Institute, at the 85th Annual Meeting of the Conference of Research Workers in Animal Diseases in Chicago, IL, Nov. 13, 2004.
  • 2003: Martijn Fenaux won the first place award (Agricultural and Biological Sciences category) at 19th Annual Research Symposium of Virginia Tech, March 26, 2003.
  • 2003: Martijn Fenaux received the 2003 VMCVM Outstanding Graduate Student Award. March 27, 2003.
  • 2003: Martijn Fenaux won the second place award at the 15th annual VMCVM Research Symposium.  June 7, 2003.
  • 2003: Padma Billam won the Best Virology Graduate Student Presentation Award sponsored by The American College of Veterinary Microbiology, at the 84th Annual Meeting of the Conference of Research Workers in Animal Diseases in Chicago, IL, Nov. 9-11, 2003.
  • 2003: Nicole McKeown won a Biosafety and Biosecurity Graduate Student Presentation Award (2nd place) sponsored by The Animal Health Institute, at 84th Annual Meeting of the Conference of Research Workers in Animal Diseases in Chicago, IL, Nov. 9-11, 2003.
  • 2002: Martijn Fenaux won the first place award (Agricultural and Biological Sciences category) at18th Annual Graduate Res Symposium of Virginia Tech, April 3, 2002.
  • 2002: F.F. Huang won the second place award (Agricultural and Biological Sciences category) at18th Annual Graduate Res Symposium of Virginia Tech, April 3, 2002.
  • 2002: Kijona Key won the first place graduate student award (Basic Science Category) at the 14th Annual VMCVM Research Symposium, June 6-7 2002.
  • 2002: Martijn Fenaux won the second place graduate student award (Basic Science Category) at the 14th Annual VMCVM Research Symposium, June 6-7, 2002.
  • 2002: Fang-Fang Huang won the second place award (Clinical Sciences category) at the 14th Annual VMCVM Research Symposium, June 6-7, 2002.
  • 2001: Martijn Fenaux won the first place award (Agricultural and Biological Sciences category) at 17th Annual Graduate Res Symposium of Virginia Tech, March 26, 2001.
  • 2001: Kijona F. Key won the second place award (Agricultural and Biological Sciences category) at 17th Annual Graduate Res Symposium of Virginia Tech, March 26, 2001.
  • 2001: Trevor Williams won the third place award (Agricultural and Biological Sciences category) at 17th Annual Graduate Res Symposium of Virginia Tech, March 26, 2001.
  • 2001:  Kijona Key won the first place graduate student award (Clinical Science Category) at the 13th Annual VMCVM Research Symposium, June 8, 2001.
  • 2001: Trevor Williams won the second place graduate student award (Clinical Science Category) at the 13th Annual VMCVM Research Symposium, June 8, 2001.
  • 2001: Martijn Fenaux won the second place graduate student award (Basic Science Category) at the 13th Annual VMCVM Research Symposium, June 8, 2001.
  • 2000: Martijn Fenaux won the 2nd place graduate student award (basic science) at the 12th Annual Research Symposium, VMCVM June 2000.

 

 

Lab Members In the News


2024

2023

2022

2021

2020

  • Meng received NIH T32 Post-DVM graduate training grant (VT news).
  • Meng named as the founding director of a new VT infectious disease center (VT news).
  • Meng spoke to NPR/RadioIQ about Virginia Tech's new Center for Emerging, Zoonotic, Arthropod-borne Pathogens (CeZAP) and the fight against COVID-19 (NPR/RadioIQ)
  • Meng answers listeners' questions about COVID-19 vaccine (Big Lick of Science podcast).
  • Meng served on a webinar panel discussing COVID-19 impact (VT news).
  • Meng interviewed for a Newsweek story about COVID-19 vaccine (Newsweek).
  • Meng spoke at the 2020 World Knowledge Forum (2020 World Knowledge Forum) and served on the “Vaccine Without Border” expert panel.
  • Meng featured in the LINK+LICENSE+LAUNCH’s Faculty Inventor Spotlights.

2019

  • Meng received the Inaugural Dr. Lorraine J. Hoffman Alumni Award from Iowa State University (ISU News) or VT News 
  • Meng received a new $2 million NIH grant to delineate the mechanism of HEV-associated high mortality during pregnancy (VT News).

2017

2016

  • Meng elected to the National Academy of Sciences (VT News).
  • Meng received the State Council of Higher Education for Virginia (SCHEV) Outstanding Faculty Award (VT News) (Roanoke times).
  • Lab alumna, Carmen Ledesma-Feliciano, is featured in the VMCVM news.
  • Meng hosts the 2016 Annual Meeting of the American Society for Virology (VT News).
  • Postdoctoral fellow, Adam Rogers, received a USDA grant to study pig coronavirus (VT News).

 2015

  • Meng gave an invited talk at the 2015 North American PRRS Symposium on Designing PRRSV Vaccines for Heterologous Protection (YouTube video).
  • Meng interviewed with CNN on a food safety story (CNN).
  • Postdoctoral fellow, Chris Overend, receives USDA fellowship grant (VT News).

 2014

  • Meng elected to the National Academy of Inventors (VT News).
  • Meng is the guest for This Week in Virology (TWiV) podcast Episode 285 ("Hokies go viral") with host Vincent Racaniello (This Week in Virology).
  • Meng featured in the Virginia Tech Magazine. (Virginia Tech Magazine).
  • Meng discussed the ongoing PEDV outbreaks with The Daily Beast (The Daily Beast).

 2013

  • Meng lab identified and characterized a pig coronavirus in the United States (VT news).
  • Postdoctoral associate, Shannon Matzinger, awarded USDA fellowship grant (VT news).
  • Meng Lab’s efforts to develop an improved PRRSV vaccine (Agency 229 report).
  • Meng received a NIH grant to study cross-species infection of hepatitis E virus (Roanoke times) (VT news).
  • Meng named a University Distinguished Professor by the Board of Visitors (VT News).
  • Meng received new NIH funding to study chronic hepatitis E (VT News)

 2012

  • Meng received the NIH T32 Post-DVM Graduate Program Training Grant (VT News).
  • Meng elected to the American Academy of Microbiology (VT News).

 2011

  • Postdoctoral associate, Scott Kenney, awarded USDA fellowship grant (VT news) (Other news media).
  • Graduate student, Caitlin Cossaboom, discovered the rabbit strain of hepatitis E virus in the United States (VT news) (Science Daily).

 2010

  • Meng served as expert consultant at a FDA panel hearing on rotavirus vaccine safety (Medpage Today). 

 2009

  • Meng responded to various media regarding the H1N1 pandemic flu (VT news).
  • Meng appointed to NIH Virology A Panel (VT news).

 2008

  • Meng ranked in the top 1% highly-cited scientists in the field of Microbiology based on total citations from 1997 to 2007 (VT News) or (Thomson Scientific feature on Meng).
  • Roanoke Times profile of X.J. Meng (Roanoke times).
  • Meng received Alumni Award for Research Excellence (VT news).
  • Meng named the inaugural Fralin Life Science Institute Senior Faculty Fellow (VT News).
  • Meng lab invented the first USDA fully-licensed commercial vaccine against porcine circovirus type 2 (PCV2) (VT News) (> 852 News Media Reports).
  • Meng elected an Honorary Diplomate of the American College of Veterinary Microbiologists (VT News).

 2007

  • Meng received Pfizer Award for Research Excellence (VT news).

 2006

  • Meng appointed to NIH Drug Discovery and Antimicrobial Resistance Panel (VT news).

 2002

  • Meng lab revealed the risk of zoonotic infection by swine hepatitis E virus (News Coverage)

 1997