Current Studies
Owners and referring vets seeking to enroll an animal in a current study should carefully review the study description and enrollment criteria below.
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The American Veterinary Medical Association Animal Health Studies Database lists hundreds of ongoing studies at sites throughout the U.S. and Canada.
Current clinical trials and translational research studies at VA-MD Vet Med
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General ItemUsing 3D echo to analyze the mitral valve in Cavalier King Charles Spaniel puppies
Purpose: To monitor the mitral valve structure of Cavalier King Charles Spaniel (CKCS) puppies and to compare the structure of CKCS puppies’ mitral valves to puppies of other breeds.
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General ItemSpironolactone to treat dogs with pulmonary hypertension and mitral valve disease
Purpose: To test whether treatment with the diuretic drug spironolactone, in addition to conventional therapy for congestive heart failure (CHF), will improve pulmonary hypertension caused by mitral valve disease.
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General ItemCavalier King Charles Spaniels and Sleep
Purpose: To understand the relationship between sleep and pain in Cavalier King Charles Spaniels and develop new methods to detect pain.
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General ItemTargeted chemotherapy for glioma brain tumors in dogs
Purpose: To determine the safety and effectiveness of a new chemotherapy drug and drug delivery method in the treatment of brain tumors (gliomas) in dogs.
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General ItemUltrasound-guided histotripsy ablation of canine brain tumors through an acoustically transparent cranial window
Purpose: To investigate the safety and antitumor activities of a new ultrasonic technology, called histotripsy, that can noninvasively destroy (ablate) tumor tissue using acoustic energy, in dogs with brain tumors.
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General ItemADAMTS-13 activity in dogs with chronic liver disease
Purpose: To evaluate the role of the ADAMTS-13 enzyme in abnormal blood clotting in dogs with chronic liver disease.
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General ItemADAMTS13 activity in dogs with presumptive idiopathic immune thrombocytopenia
Purpose: To evaluate the role of ADAMTS13, an enzyme related to blood clotting, in dogs with presumptive idiopathic immune thrombocytopenia.
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General ItemBlood coagulation in cats with hypertrophic cardiomyopathy (HCM)
Purpose: To evaluate cats with hypertrophic cardiomyopathy (HCM) for abnormal blood clotting activity.
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General ItemAssessing Postoperative Pain in Pigs After Celiotomy or Laparoscopic Spay
Purpose: To test if minimally-invasive ovary removal will have fewer complications and improve recovery in pet pigs compared to the traditional abdominal surgery ovariohysterectomy spay technique
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General ItemEvaluating the effects of complete tumor histotripsy ablation and immunostimulation in canine osteosarcoma
Purpose: To evaluate the effects of histotripsy, a novel treatment for that can destroy tissue without radiation or heat, on dogs with osteosarcoma.
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General ItemSpeckle tracking echocardiography as a new screening tool for dilated cardiomyopathy in Doberman Pinschers
Purpose: To test whether speckle tracking echocardiography will be able to detect changes in the hearts of Dobermans who have abnormal 24-hour Holter monitoring but normal standard echocardiograms.
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General ItemDoes body condition affect fertility and reproductive performance in the bitch?: Comparing reproductive performance of overweight/obese and lean bitches
Purpose: To identify how body condition, exercise, and nutrition affect the reproductive potential of female dogs and the health of their puppies.
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General ItemAdvanced hemodynamic monitoring in anesthetized dogs
Purpose: To test whether using advanced cardiac monitoring techniques provides a more accurate measurement of cardiac output and helps clinicians better determine when anesthetized dogs need more cardiovascular support to maintain a healthy cardiac output.
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General ItemThe Weight of Whelping: A Survey on Whelping Events in the Broodbitch
Purpose: To create a large database on the timing of whelping milestones in dogs.
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General ItemEpitope screening: on the way to a vaccine for Equine Protozoal Myeloencephalitis (EPM)
Purpose: To identify immune molecules that may be protective against S. neurona infection as a first step towards developing a vaccine against EPM.
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General ItemTesting a new treatment for metastatic osteosarcoma in the lungs
Purpose: To measure the effects of H-FIRE, a therapy that can destroy tissue without radiation or heat, on dogs with metastatic osteosarcoma in their lungs.
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General ItemPredictors of the age of onset of chamber enlargement in Cavalier King Charles Spaniel dogs
Purpose: To evaluate if young CKCSs with mild mitral regurgitation develop heart enlargement earlier than young CKCSs with no mitral regurgitation.
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General ItemComparing lactation performance and puppy growth of overweight/obese and lean bitches
Purpose: To identify how body condition and nutrition affect the whelping process and milk composition or production of female dogs and the health of their puppies.
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General ItemReal-time three-dimensional evaluation of the feline heart
Purpose: To assess the feasibility of performing 3D echocardiography in healthy cats and to establish the standard range of dimensions for measuring the heart chambers in healthy cats
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General ItemEvaluation of urine liquid biopsy for canine appendicular osteosarcoma (bone cancer)
Purpose: To evaluate the use of urine samples as a liquid biopsy tool to monitor disease progression in canine osteosarcoma
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General ItemHistotripsy ultrasound therapy effectiveness on equine sarcoids
Purpose: To evaluate the effectiveness of histotripsy as a non-invasive therapeutic approach for treating equine sarcoids.