Caswell Laboratory
INQUIRIES
Clayton Caswell, PhD
Associate Professor, Bacteriology
Lab: 115, 118B
Email: caswell@vt.edu
540-231-5591/3825
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Bio ItemClayton C. Caswell, PhD , bio
Associate Professor, Bacteriology
About Caswell Lab
Our research team is focused on identifying and characterizing systems that allow pathogenic bacteria to cause disease in humans and animals.
We are interested in defining the genetic and biochemical elements that allow bacteria to infect their hosts, and in particular, our group studies regulatory RNAs, transcriptional control of gene expression, and stress adaptation pathways. In the end, our long-term goals are to exploit these bacterial systems for the development of novel therapeutic agents and vaccines against bacterial infections.
Inside the Lab
Every year, Caswell Lab students attend national and International conferences to present on their findings. Previous conference opportunities include: Wind River Prokaryotic Biology, Virginia ASM, MAMP, Brucellosis.
Beyond the work in the lab, our students are able to unwind during our holiday parties, intramural leagues, local races, and exploring Blacksburg!
We can't do this without you!
Trainees, including undergraduate students, graduate students, and postdoctoral researchers have been and will continue to be critical for the research mission of our laboratory, and, collectively, we are committed to training, mentoring, and supporting our trainees.
If you are interested in joining our team to study mechanisms of bacterial pathogenesis, please contact Clay Caswell to learn more about opportunities in our lab.

News
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Article ItemClayton Caswell's laboratory awarded three National Institutes of Health research grants , article
The three grants, each driven by a different graduate student, highlight the diverse and impactful research conducted in Caswell's lab in the Virginia-Maryland College of Veterinary Medicine.
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Article ItemVMCVM Faculty Spotlight: Clay Caswell , article
Clay Caswell, who joined the veterinary college in 2013, cherishes mentoring trainees in the lab by witnessing emerging scientists develop innovative projects and fall in love with science. Guided by the simple advice to "listen", he finds fulfillment in every breakthrough while unwinding with puzzles and a cold beer.
- Sinorhizobium Meliloti YbeY Is a Zinc-Dependent Single-Strand Specific Endoribonuclease That Plays an Important Role in 16S Ribosomal RNA Processing
- Quantitative Variation in m.3243A > G Mutation Produce Discrete Changes in Energy Metabolism
- Assessment of Survival and Replication of Brucella spp. in Murine Peritoneal Macrophages
- Defining the regulatory mechanism of NikR, a nickel-responsive transcriptional regulator, in Brucella abortus
- Characterization of Three Small Proteins in Brucella abortus Linked to Fucose Utilization
- Endoribonuclease YbeY Is Linked to Proper Cellular Morphology and Virulence in Brucella abortus
- An account of evolutionary specialization: the AbcR small RNAs in the Rhizobiales
- Proline utilization system is required for infection by the pathogenic α-proteobacterium Brucella abortus
- A 6-Nucleotide Regulatory Motif within the AbcR Small RNAs of Brucella abortus Mediates Host-Pathogen Interactions
- Sibling sRNA RyfA1 Influences Shigella dysenteriae Pathogenesis
- Enhanced Mucosal Defense and Reduced Tumor Burden in Mice with the Compromised Negative Regulator IRAK-M
- Brucella abortus Strain 2308 Wisconsin Genome: Importance of the Definition of Reference Strains
- Transcriptome-Wide Identification of Hfq-Associated RNAs in Brucella suis by Deep Sequencing
- Unique Footprint in the scl1.3 Locus Affects Adhesion and Biofilm Formation of the Invasive M3-Type Group A Streptococcus
- Coordinated zinc homeostasis is essential for the wild-type virulence of Brucella abortus
- A LysR-family transcriptional regulator required for virulence in Brucella abortus is highly conserved among the α-proteobacteria
- Bacterial persistence: finding the "sweet spot"
- Sibling rivalry: related bacterial small RNAs and their redundant and non-redundant roles
- Diverse genetic regulon of the virulence-associated transcriptional regulator MucR in Brucella abortus 2308
- The Brucella abortus general stress response system regulates chronic mammalian infection and is controlled by phosphorylation and proteolysis