Principal investigator Theus awarded NIH R01 grant
June 1, 2021
Principal investigator Michelle Theus, associate professor of molecular and cellular neurobiology in the Department of Biomedical Sciences and Pathobiology, and co-investigator Chang Lu, Fred W. Bull Professor of Chemical Engineering in the College of Engineering, have been awarded a four-year R01 grant from the National Institutes of Health's (NIH) National Institute of Neurological Disorders and Stroke (NINDS) to investigate the potential for restorative innate immune immunological intervention to improve traumatic brain injury.
Divergent age-dependent peripheral innate immune response after traumatic brain injury
DURATION OF AWARD
June 1, 2021 — March 31, 2025
KEY FACULTY PERSONNEL
PI/PD: Michelle Theus
CO-I: Chang Lu
Limited information exists pertaining to the physiological relevance of innate immune regulation across the age spectrum following traumatic brain injury (TBI). Completion of these studies will advance our understanding of the key regulators involved in monocyte/macrophage responses and neurovascular health in TBI pathophysiology. Exploiting the pro-resolving phenotype of juvenile-derived peripheral monocyte/macrophages may provide a novel restorative intervention aimed at improving TBI outcomes and reveal novel targets for drug discovery.