Weger-Lucarelli Laboratory
About the Viral Genetics and Host Interactions Lab
Virus-Host Interactions
We believe that we can reduce disease burden through collaborative and innovative biomedical research performed in a fun environment. We are interested in knowing how viruses and their hosts interact. Specifically, some questions we have are:
- Why do some people get worse disease following infection?
- What factors influence virus transmission and evolution?
- Can we use the knowledge gained by answering these questions to devise novel strategies to block transmission or prevent disease?
Mosquito-borne viruses like Zika virus (ZIKV), dengue virus (DENV) and chikungunya virus (CHIKV) (also known as arboviruses i.e. arthropod-borne viruses) cause hundreds of millions of infections annually. These viruses are constantly evolving, adapting to changing host environments that can eventually lead to outbreaks. The VG-HI lab is interested in understanding the shifting host factors that put pressure on arboviruses to evolve in order to design strategies to disrupt their transmission.
In order to study arbovirus-host interactions, we incorporate a variety of disciplines and approaches, including in vivo mouse and mosquito models, cell culture, molecular biology, immunology, next-generation sequencing, and more.
Primary Investigator
Dr. James Weger-Lucarelli
Associate Professor | Viral Genetics and Host Interactions
I am originally from Madison, Wisconsin. I obtained both my Bachelors in Medical Microbiology and Immunology and my PhD in Comparative Biomedical Sciences from the University of Wisconsin. I then did a postdoc in Greg Ebel's lab at Colorado State University followed by a second postdoc in Marco Vignuzzi's lab at the Pasteur Institute in Paris, France. My training has mostly been in virology, vaccinology, and virus evolution with a focus on mosquito borne viruses. I am interested in using molecular and evolution-based approaches to generate new viruses that can be used as vaccines, therapeutics, or cancer treatments. I'm also interested in gaining a better understanding of virus-host interactions towards developing new antivirals or therapeutics that can be used to target a wide array of viral diseases. I'm also highly passionate and motivated about properly training the next generation of young scientists. Finally, I'm passionate about maintaining physical, mental, and spiritual health.
Current team members
Parisa Nikeghbal, PhD
Postdoctoral Associate
Parisa earned her B.S. in Medical Laboratory Sciences in Iran before moving to the United States to pursue her Ph.D. in Biomedical Sciences at the University of New Mexico School of Medicine and Comprehensive Cancer Center. Her doctoral research focused on tumor immunology, particularly how tumor-associated macrophages shape the ovarian cancer microenvironment and influence therapeutic response, using patient-derived 3D cancer models.
After completing her Ph.D. in 2025, she joined Virginia Tech as a postdoctoral associate, where she worked on human liver organoids and iPSC-derived cell models for virology research. In August 2026, she joined the Weger-Lucarelli Lab, where her research focuses on developing 3D and iPSC-derived cellular models to study virus–host interactions, antiviral responses, and oncolytic viruses. Outside the lab, Parisa enjoys running, baking, and spending time with family.
Kailynn Roberts
Coming soon.
Samar Sayedyahossein, MD, PhD
Research Assistant Professor
Samar Sayedyahossein is a Research Assistant Professor in the Weger-Lucarelli Lab. Her research focuses on virus–host interactions and the mechanisms through which alphaviruses induce cell death in glioblastoma models. She is particularly interested in understanding the host signaling pathways that modulate viral infection, replication, and tumor cell responses.
Katie Tiller, MS
PHD Student
Katie joined the VG-HI lab in the fall of 2022, and is a local of Southwest Virginia. She worked as a Biology and Anatomy teacher at Bland County High School for 5 years. During that time, she obtained her M.S. in Microbiology and Cell Science from the University of Florida. She previously obtained her B.S. in Biology from Radford University, where she was a 4 year member of the Radford University Dance Team. Katie is also an instructor/choreographer at Bluefield Dance Theatre where she has taught dance for over 16 years. She also serves as a board member, performer, choreographer, and instructor for Adaire Theatre in Pulaski, VA.
Tyler Williams, MS
Research Laboratory Technician
Before joining the Weger-Lucarelli lab, Tyler earned his bachelor’s degree at Virginia Tech and worked in the natural resources field as a technician for various wildlife projects including endangered species conservation, genetic diversity assessments, and long-term effects of the Deepwater Horizon oil spill. Tyler went on to receive his master’s degree at Louisiana State University and then worked as a research technician at the USDA Honeybee Breeding and Genomic Facility studying the role nutrition plays in disease outcomes for honeybees. In this current position, Tyler is working to develop Sindbis virus replicons to facilitate gene knockout in cell culture, establish protocols using pseudoviruses to measure neutralizing antibody levels in wildlife samples, and to support various laboratory needs. Outside of research Tyler spends time cooking or baking and enjoys outdoor activities like fishing, bird watching, and bee keeping.
Aryn Wright
PhD Student
Coming soon.
Wegar Lab Alumni
- Pallavi Rai, PhD
- Chelsea Cereghino, PhD
- Ian Taylor, MS
- Christina Chuong, PhD
- Jefferey Marano, PhD
- Emily Webb, PhD
- Muddassar Hameed, PhD
- Charlie Amoia, PhD
- Blake Flinchum, MS
- Sam Rodgers, MPH
- Tyler Bates, MS
- Jeremy Thomas, MPH
- Alex Solomon
- Julie Nguyen
- Shamima Akter
Thank you to our previous lab members who are off doing amazing things. We miss you!
- Visit the Weger-Lucarelli Google Scholar page for a full list of publications.
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Board of Visitors recognizes veterinary college faculty , articleMany congratulations to veterinary college faculty recognized by the Virginia Tech Board of Visitors at the June 3 meeting.
Date: Jun 05, 2026 - -
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Class of 2024: A brush with illness opened Alex Solomon’s eyes to immunology research , articleAfter graduation, Solomon is headed to a Ph.D. program in immunology.
Date: May 14, 2024 - -
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Meet two Virginia Tech research couples who share a special bond , articleTwo Fralin Life Sciences Institute research couples — Brenda Winkel and Jim Westwood, along with Nisha Duggal and James Weger— share insight on how their worlds of being partners in life intertwine with their roles in academia.
Date: Feb 13, 2024 - -
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Interdisciplinary team receives $5 million grant to explore COVID-19 virus ecology at the human-animal interface , articleVirginia Tech researchers will explore the risk of SARS-CoV-2, the virus that causes COVID-19, infections in wildlife communities and how those risks could affect humans.
Date: Oct 23, 2023 - -
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Collaborative study focuses on using computer algorithms to find molecular adaptations to improve COVID-19 drugs , articleMoving through all the phases of the study would not have been possible without extensive cross-departmental collaboration.
Date: Oct 18, 2023 - -
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James Weger-Lucarelli receives grant to develop tools to aid researchers in study of RNA viruses , articleWeger-Lucarelli will use the $150,000 grant from the National Institute of Allergy and Infectious Diseases to develop easy-to-use tools and techniques that will allow more researchers to study RNA viruses and their mutations.
Date: Aug 16, 2023 - -
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Turning observations into health interventions: Graduate students continue to make an impact , articleStudents in Virginia Tech’s Translational Biology, Medicine, and Health graduate program will pursue impactful health science careers after completing their degrees.
Date: Jun 28, 2023 - -
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Virginia Tech researchers address the grand challenges of pandemic prediction and prevention , articleT.M. Murali, a professor in the Department of Computer Science, along with several colleagues from across Virginia Tech, has received a $1 million National Science Foundation grant to identify expedient, efficient, cost-effective options for the prevention and containment of zoonotic viruses.
Date: May 01, 2026 - -
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Collaborative research leads to potential identification of SARS-CoV-2 human emergence and new COVID-19 therapeutics , articleBuilding on their recently published research in Cell about COVID-19 transmission, the research group’s vision is to use recent advancements in relative free energy calculations and computing resources to rationally design and quantitatively predict drugs that could make a difference in treatment of the virus.
Date: Dec 10, 2021 - -
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Virginia Tech research sees continued growth , articleResearch expenditures are up and sponsored awards have increased by 15 percent, building upon the prior year’s expenditure total of $542 million, despite the impact of COVID-19 felt nationally by higher education institutes, according to preliminary fiscal year-end reports.
Date: Sep 08, 2020 - -
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Virginia Tech researchers establish a reverse genetics system to facilitate COVID-19 research , articleResearchers from the Virginia-Maryland College of Veterinary Medicine and the Fralin Life Sciences Institute are establishing a reverse genetics system for SARS-CoV-2 that will serve as the basis for vaccine design and for studying viral mutations associated with COVID-19 severity and viral transmission.
Date: Jun 05, 2020 -
Please contact us!
We love to collaborate and participate in exciting science of any kind!
Virginia Tech Center for One Health Research
1410 Prices Fork Road
Blacksburg, VA 24060